南方科技大学知识苑(SUSTech KC): Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models

题名	Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models
作者	Li，Yingjun1,2 ; Cao，Liu 3; Li，Ge 4; Cong，Feng 4; Li，Yunfeng 4; Sun，Jing 5; Luo，Yinzhu 4; Chen，Guijiang 4; Li，Guanguan1 ; Wang，Ping1 ; Xing，Fan 3; Ji，Yanxi 3; Zhao，Jincun 5; Zhang，Yu 4; Guo，Deyin 3; Zhang，Xumu1,2
通讯作者	Zhang，Xumu
发表日期	2021
DOI	10.1021/acs.jmedchem.0c01929
发表期刊	JOURNAL OF MEDICINAL CHEMISTRY 影响因子和分区
ISSN	0022-2623
EISSN	1520-4804
卷号	65 期号:4
摘要	The outbreak of coronavirus disease 2019 (COVID-19) has resulted in a global pandemic due to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the time of this manuscript's publication, remdesivir is the only COVID-19 treatment approved by the United States Food and Drug Administration. However, its effectiveness is still under question due to the results of the large Solidarity Trial conducted by the World Health Organization. Herein, we report that the parent nucleoside of remdesivir, GS-441524, potently inhibits the replication of SARS-CoV-2 in Vero E6 and other cell lines. Challenge studies in both an AAV-hACE2 mouse model of SARS-CoV-2 and in mice infected with murine hepatitis virus, a closely related coronavirus, showed that GS-441524 was highly efficacious in reducing the viral titers in CoV-infected organs without notable toxicity. Our results support that GS-441524 is a promising and inexpensive drug candidate for treating of COVID-19 and other CoV diseases.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
重要成果	ESI高被引
学校署名	第一 ; 通讯
资助项目	Shenzhen Science and Technology Innovation Committee[ZDSYS20190902093215877] ; Shenzhen Science and Technology Program["JSGG20200225150431472","KQTD20180411143323605"] ; Shenzhen Bay Laboratory[SZBL2019062801006] ; National Natural Science Foundation of China[32041002,81620108020]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000797940600004
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
Scopus记录号	2-s2.0-85100733554
来源库	Scopus
引用统计	被引频次[WOS]：89
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/221822
专题	理学院_化学系理学院前沿与交叉科学研究院
作者单位	1.Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis,Department of Chemistry,College of Science,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China 2.Medi-X,Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China 3.Centre for Infection and Immunity Studies,School of Medicine,Sun Yat-sen University,Shenzhen, Guangdong,518107,China 4.Guangdong Province Key Laboratory of Laboratory Animals,Guangdong Laboratory Animals Monitoring Institute,Guangzhou, Guangdong,510663,China 5.State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,First Affiliated Hospital,Guangzhou Medical University,Guangzhou, Guangdong,510182,China
第一作者单位	化学系; 理学院; 前沿与交叉科学研究院
通讯作者单位	化学系; 理学院; 前沿与交叉科学研究院
第一作者的第一单位	化学系; 理学院
推荐引用方式 GB/T 7714	Li，Yingjun,Cao，Liu,Li，Ge,et al. Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models[J]. JOURNAL OF MEDICINAL CHEMISTRY,2021,65(4).
APA	Li，Yingjun.,Cao，Liu.,Li，Ge.,Cong，Feng.,Li，Yunfeng.,...&Zhang，Xumu.(2021).Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.JOURNAL OF MEDICINAL CHEMISTRY,65(4).
MLA	Li，Yingjun,et al."Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models".JOURNAL OF MEDICINAL CHEMISTRY 65.4(2021).