Dichlorodiphenyltrichloroethane metabolites inhibit DNMT1 activity which confers methylation-specific modulation of the sex determination pathway

Hu，Junjie1; Yang，Yan2,3; Lv，Xiaomei1; Lao，Zhilang1; Yu，Lili4

2021-06-15

10.1016/j.envpol.2021.116828

ENVIRONMENTAL POLLUTION   影响因子和分区

0269-7491

1873-6424

The study provides a new insight into DDT-induced abnormalities in sexual development.

DDT metabolites DNA methylation DNA methyltransferase 1 Sexual determination Virtual screening

SCI ; EI

英语

通讯

WOS:000644822400001

20211210125568

Alkylation ; Binding energy ; Biomolecules ; Cell culture ; Ethylene ; Gene expression ; Health risks ; Metabolites ; Methylation ; Molecular dynamics ; Stem cells

Biological Materials and Tissue Engineering:461.2 ; Health Care:461.7 ; Biology:461.9 ; Biochemistry:801.2 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Chemical Operations:802.3 ; Organic Compounds:804.1

ENVIRONMENT/ECOLOGY

2-s2.0-85102881136

Scopus

1.School of Environment and Civil Engineering,Dongguan University of Technology,Dongguan,523808,China
2.Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control,Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control,School of Environmental Science and Engineering,Institute of Environmental Health and Pollution Control,Guangdong University of Technology,Guangzhou,510006,China
3.Synergy Innovation Institute of GDUT,Shantou,515041,China
4.Translational Medicine Collaborative Innovation Center,The First Affiliated Hospital (Shenzhen People's Hospital),Southern University of Science and Technology,Shenzhen,1017 Dongmen North Road, Luohu District,518020,China

Hu，Junjie,Yang，Yan,Lv，Xiaomei,et al. Dichlorodiphenyltrichloroethane metabolites inhibit DNMT1 activity which confers methylation-specific modulation of the sex determination pathway[J]. ENVIRONMENTAL POLLUTION,2021,279.

Hu，Junjie,Yang，Yan,Lv，Xiaomei,Lao，Zhilang,&Yu，Lili.(2021).Dichlorodiphenyltrichloroethane metabolites inhibit DNMT1 activity which confers methylation-specific modulation of the sex determination pathway.ENVIRONMENTAL POLLUTION,279.

Hu，Junjie,et al."Dichlorodiphenyltrichloroethane metabolites inhibit DNMT1 activity which confers methylation-specific modulation of the sex determination pathway".ENVIRONMENTAL POLLUTION 279(2021).