Iridium-catalyzed asymmetric hydrogenation of: N-phosphinoylimine

Yin，Congcong1; Pan，Yingmin1; Zheng，Longsheng1; Lin，Bijin1; Wen，Jialin1,2; Zhang，Xumu1,3

2021-03-21

10.1039/d0qo01286f

Organic Chemistry Frontiers   影响因子和分区

2052-4110

2052-4129

Enantioselective hydrogenation of imines involving an outer-sphere mechanism was achieved. On catalysis with an iridium tridentate catalyst, prochiral N-phosphinoylimines were hydrogenated with high enantioselectivities. The turnover number could reach 10000. This method could be applied in the synthesis of chiral amines with an α-stereocenter. Indeed, cinacalcet was successfully prepared with a remarkably high enantioselectivity using this method. This journal is

SCI ; IC ; CCR ; EI

英语

第一 ; 通讯

Shenzhen Bay Laboratory[SZBL2019062801006]

Chemistry

Chemistry, Organic

WOS:000631592900015

ROYAL SOC CHEMISTRY

20211310140217

Amines ; Catalysis ; Enantioselectivity ; Iridium

Precious Metals:547.1 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Organic Compounds:804.1

2-s2.0-85103076004

Scopus

1.Shenzhen Grubbs Institute and Department of Chemistry,Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China
2.Southern University of Science and Technology,Academy for Advanced Interdisciplinary Studies,Shenzhen, Guangdong,518055,China
3.Shenzhen Bay Laboratory,Shenzhen,518132,China

Yin，Congcong,Pan，Yingmin,Zheng，Longsheng,et al. Iridium-catalyzed asymmetric hydrogenation of: N-phosphinoylimine[J]. Organic Chemistry Frontiers,2021,8(6):1223-1226.

Yin，Congcong,Pan，Yingmin,Zheng，Longsheng,Lin，Bijin,Wen，Jialin,&Zhang，Xumu.(2021).Iridium-catalyzed asymmetric hydrogenation of: N-phosphinoylimine.Organic Chemistry Frontiers,8(6),1223-1226.

Yin，Congcong,et al."Iridium-catalyzed asymmetric hydrogenation of: N-phosphinoylimine".Organic Chemistry Frontiers 8.6(2021):1223-1226.