Hypoxia associated multi-omics molecular landscape of tumor tissue in patients with hepatocellular carcinoma

Zhang，Qiangnu1,2; Qiao，Lijun1,2; Liu，Quan1,2; Kong，Xiangpan4; Hu，Jun5; Hu，Weibin1,3; Wu，Zongze1,3; Li，Mingyue1,3; Liu，Liping1,3

2021-03-15

10.18632/aging.202723

Aging-US   影响因子和分区

1945-4589

The present study was designed to update the knowledge about hypoxia-related multi-omic molecular landscape in hepatocellular carcinoma (HCC) tissues. Large-size HCC datasets from multiple centers were collected. The hypoxia exposure of tumor tissue from patients in 10 HCC cohorts was estimated using a novel HCC-specific hypoxia score system constructed in our previous study. A comprehensive bioinformatical analysis was conducted to compare hypoxia-associated multi-omic molecular features in patients with a high hypoxia score to a low hypoxia score. We found that patients with different exposure to hypoxia differed significantly in transcriptomic, genomic, epigenomic, and proteomic alterations, including differences in mRNA, microRNA (miR), and long non-coding RNA (lncRNA) expression, differences in copy number alterations (CNAs), differences in DNA methylation levels, differences in RNA alternative splicing events, and differences in protein levels. HCC survival-associated molecular events were identified. The potential correlation between molecular features related to hypoxia has also been explored, and various networks have been constructed. We revealed a particularly comprehensive hypoxia-related molecular landscape in tumor tissues that provided novel evidence and perspectives to explain the role of hypoxia in HCC. Clinically, the data obtained from the present study may enable the development of individualized treatment or management strategies for HCC patients with different levels of hypoxia exposure.

hepatocellular carcinoma hypoxia microenvironment multi-omics non-coding RNA

SCI

英语

通讯

Science and Technology Innovation Commission of Shenzhen[KQJSCX20180321164801762] ; National Science Foundation for Young Scientists of China[81903013]

Cell Biology ; Geriatrics & Gerontology

Cell Biology ; Geriatrics & Gerontology

WOS:000629616300019

IMPACT JOURNALS LLC

2-s2.0-85102793585

Scopus

1.Department of Hepatobiliary and Pancreas Surgery,The Second Clinical Medical College,Jinan University,Shenzhen People’s Hospital,Shenzhen,518020,China
2.Integrated Chinese and Western Medicine Postdoctoral Research Station,Jinan University,Guangzhou,510632,China
3.Department of Hepatobiliary and Pancreas Surgery,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
4.Faculty of Science and Engineering,University of Groningen,Groningen,9747,Netherlands
5.Institute of Pathology,University Clinic of Heidelberg,Heidelberg,69120,Germany

Zhang，Qiangnu,Qiao，Lijun,Liu，Quan,et al. Hypoxia associated multi-omics molecular landscape of tumor tissue in patients with hepatocellular carcinoma[J]. Aging-US,2021,13(5):6525-6553.

Zhang，Qiangnu.,Qiao，Lijun.,Liu，Quan.,Kong，Xiangpan.,Hu，Jun.,...&Liu，Liping.(2021).Hypoxia associated multi-omics molecular landscape of tumor tissue in patients with hepatocellular carcinoma.Aging-US,13(5),6525-6553.

Zhang，Qiangnu,et al."Hypoxia associated multi-omics molecular landscape of tumor tissue in patients with hepatocellular carcinoma".Aging-US 13.5(2021):6525-6553.