Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity

Shi，Zhichao1,2; Fan，Tingting2,3,4; Zhang，Xun1,2; Zhan，Feng1,2; Wang，Zhe1,2; Zhao，Lei1,2; Lin，Jin Shun1,2; Jiang，Yuyang1,2,3,4,5

2021

10.1002/adsc.202001569

ADVANCED SYNTHESIS & CATALYSIS   影响因子和分区

1615-4150

1615-4169

A Y(OTf)-catalyzed [3+2] cycloaddition of 1,3,5-triazinanes with donor-acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation of imidazolidines through an S1-like pathway. Furthermore, these imidazolidines exhibit promising anti-tumor activity against a series of human cancer cell lines. (Figure presented.).

1,3,5-Triazinanes Anti-tumor activity Cycloaddition Donor-acceptor aziridines Imidazolidines

SCI

英语

其他

Shenzhen Development and Reform Committee[2019156] ; Shenzhen Science, Technology and Innovation Commission[JCYJ20180306174248782] ; Department of Science and Technology of Guangdong Province[2017B030314083] ; Shenzhen Bay Laboratory[SZBL2019062801009]

Chemistry

Chemistry, Applied ; Chemistry, Organic

WOS:000634752100001

WILEY-V C H VERLAG GMBH

2-s2.0-85103398820

Scopus

1.Department of Chemistry,Tsinghua University,Beijing,100084,China
2.The State Key Laboratory of Chemical Oncogenomics,Key Laboratory of Chemical Biology,Tsinghua Shenzhen International Graduate School,Tsinghua University,Shenzhen,518055,China
3.Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
4.Shenzhen Bay Laboratory,Shenzhen,518055,China
5.School of Pharmaceutical Sciences,Tsinghua University,Beijing,100084,China

Shi，Zhichao,Fan，Tingting,Zhang，Xun,et al. Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity[J]. ADVANCED SYNTHESIS & CATALYSIS,2021,363(10).

Shi，Zhichao.,Fan，Tingting.,Zhang，Xun.,Zhan，Feng.,Wang，Zhe.,...&Jiang，Yuyang.(2021).Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity.ADVANCED SYNTHESIS & CATALYSIS,363(10).

Shi，Zhichao,et al."Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity".ADVANCED SYNTHESIS & CATALYSIS 363.10(2021).