| 题名 | BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma |
| 作者 | |
| 通讯作者 | Wang，Jin |
| 发表日期 | 2021
|
| DOI | |
| 发表期刊 | |
| ISSN | 1945-4589
|
| 卷号 | 13期号:5页码:7499-7516 |
| 摘要 | Bradykinin receptor B2 (BDKRB2) has been reported as an oncogene in several malignancies. In glioma, the role of BDKRB2 remains unknown. This study aimed at investigating its clinical significance and biological function in glioma at the transcriptional level. We selected 301 glioma patients with microarray data from CGGA database and 697 with RNAseq data from TCGA database. Transcriptome and clinical data of 998 samples were analyzed. Statistical analysis and figure generating were performed with R language. BDKRB2 expression showed a positive correlation with the WHO grade of glioma. BDKRB2 was increased in IDH wildtype and mesenchymal subtype of glioma. Gene ontology analysis demonstrated that BDKRB2 was profoundly associated with extracellular matrix organization in glioma. GSEA analysis revealed that BDKRB2 was particularly correlated with epithelial-to-mesenchymal transition (EMT). GSVA analysis showed that BDKRB2 was significantly paralleled with several EMT signaling pathways, including PI3K/AKT, hypoxia, and TGF-β. Moreover, BDKRB2 expression was significantly correlated with key biomarkers of EMT, especially with N-cadherin, snail, slug, vimentin, TWIST1, and TWIST2. Finally, higher BDKRB2 indicated significantly shorter survival for glioma patients. In conclusion, BDKRB2 was associated with more aggressive phenotypes of gliomas. Furthermore, BDKRB2 was involved in the EMT process and could serve as an independent prognosticator in glioma. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 通讯
|
| 资助项目 | Medical Scientific Research Foundation of Shenzhen Health Commission[szfz2018022]
; Shenzhen Science and Technology Innovation Foundation[JCYJ20190806150005453]
; Futian Public Welfare Scientific Research Project[FTWS2020099]
|
| WOS研究方向 | Cell Biology
; Geriatrics & Gerontology
|
| WOS类目 | Cell Biology
; Geriatrics & Gerontology
|
| WOS记录号 | WOS:000632038400006
|
| 出版者 | |
| Scopus记录号 | 2-s2.0-85103089744
|
| 来源库 | Scopus
|
| 引用统计 |
被引频次[WOS]：14
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/222786 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Department of Pediatrics,Futian Women and Children Health Institute,Shenzhen,518045,China 2.Department of Emergency,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Yang，Ying,Wang，Jin,Shi，Fei,et al. BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma[J]. Aging-US,2021,13(5):7499-7516.
|
| APA |
Yang，Ying,Wang，Jin,Shi，Fei,Shan，Aijun,Xu，Shihai,&Lv，Wen.(2021).BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.Aging-US,13(5),7499-7516.
|
| MLA |
Yang，Ying,et al."BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma".Aging-US 13.5(2021):7499-7516.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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