DNA Cleavage by Chemically Exfoliated Molybdenum Disulfide Nanosheets

Zhao，Yingcan1; Xu，Jiayi1; Jiang，Xingyu1,2

2021

10.1021/acs.est.1c00115

ENVIRONMENTAL SCIENCE & TECHNOLOGY   影响因子和分区

0013-936X

1520-5851

Chemically exfoliated MoS2 (ce-MoS2) nanosheets have been widely used in biomedical and environmental fields. Some in vitro studies demonstrated that ce-MoS2 might induce toxicity. However, the understanding of the mechanism of potential toxicity is lacking. In this study, we found that ce-MoS2 could directly induce breakage of double-stranded DNA with or without an external energy input, making it different from other two-dimensional nanomaterials. In a dark environment, the DNA cleavage exhibited a pH-dependent trend due to reactive oxygen species generation under different pH values. Under photoirradiation, DNA cleavage could be enhanced. This study provides insights into the potential environmental risk and toxicity of ce-MoS2 in the aquatic environment.

SCI ; EI

英语

NI论文

第一 ; 通讯

WOS:000636727200059

20211410168700

DNA ; Layered semiconductors ; Nanosheets ; Sulfur compounds ; Toxicity

Biological Materials and Tissue Engineering:461.2 ; Health Care:461.7 ; Nanotechnology:761 ; Solid State Physics:933

ENVIRONMENT/ECOLOGY

2-s2.0-85102965327

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Shenzhen Bay Laboratory,Shenzhen,518055,China

Zhao，Yingcan,Xu，Jiayi,Jiang，Xingyu. DNA Cleavage by Chemically Exfoliated Molybdenum Disulfide Nanosheets[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2021,55:4037-4044.

Zhao，Yingcan,Xu，Jiayi,&Jiang，Xingyu.(2021).DNA Cleavage by Chemically Exfoliated Molybdenum Disulfide Nanosheets.ENVIRONMENTAL SCIENCE & TECHNOLOGY,55,4037-4044.

Zhao，Yingcan,et al."DNA Cleavage by Chemically Exfoliated Molybdenum Disulfide Nanosheets".ENVIRONMENTAL SCIENCE & TECHNOLOGY 55(2021):4037-4044.