A disease progression prediction model and nervous system symptoms in coronavirus disease 2019 patients

Zhao，Yu1; Wang，Fuxiang2; Dong，Gaolei1; Sheng，Qi1; Feng，Shiyan2

2021

American Journal of Translational Research   影响因子和分区

1943-8141

This study aimed to investigate factors affecting coronavirus disease 2019 (COVID-19) progression, also to explore the clinical features and prognosis of nervous system symptom (NSS) involved COVID-19 patients. 417 COVID-19 patients were analyzed in this retrospective study, and they were clinically classified as severe patients and non-severe patients. According to NSS involved status, COVID-19 patients were further divided into NSS patients and non-NSS patients. Elderly cases, males, common comorbidities, NSS, respiratory/cardiovascular/gastrointestinal symptoms, bilateral lesion, multifocal lesion, bacterial infection, bacterial & fungal infection were more common in severe patients compared to non-severe patients. Meanwhile, severe COVID-19 patients showed increased baseline APTT, TT, D-dimer, CRP, ESR, CK-MB, creatine kinase, AST, ALT, creatinine, but decreased baseline platelet level, lymphocyte, albumin, GFR compared to non-severe patients. Notably, the continuous differences of lymphocyte, D-dimer, CRP, AST, ALT, albumin, GFR between severe patients and non-severe patients during treatment were observed. Age, NSS, bacterial & fungal infection, CRP and creatinine were further identified as independent risk factors for severe COVID-19, which could predict severe COVID-19 with area under curve of 0.861. Furthermore, severe patients presented with worse prognosis. Regrading NSS patients, they were related to older age, surgery history, diabetes comorbidities, respiratory/cardiovascular/gastrointestinal symptoms, bilateral lesion, multifocal lesion, bacterial infection, bacterial & fungal infection and more dysregulated laboratory indexes compared to non-NSS patients. Besides, NSS patients were correlated with poor prognosis to some extent. More intensive attention should be paid to COVID-19 patients with severe-disease risk factors and those with NSS involvement, in case of rapid deterioration.

Coronavirus disease 2019 Disease progression predicting model Disease severity Laboratory indexes Nervous system symptom Prognosis

英语

第一 ; 通讯

2-s2.0-85099363745

Scopus

1.Department of Neurology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,The Second Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518114,China
2.Department for Infectious Diseases,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,The Second Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518114,China

Zhao，Yu,Wang，Fuxiang,Dong，Gaolei,et al. A disease progression prediction model and nervous system symptoms in coronavirus disease 2019 patients[J]. American Journal of Translational Research,2021,12(12):8192-8207.

Zhao，Yu,Wang，Fuxiang,Dong，Gaolei,Sheng，Qi,&Feng，Shiyan.(2021).A disease progression prediction model and nervous system symptoms in coronavirus disease 2019 patients.American Journal of Translational Research,12(12),8192-8207.

Zhao，Yu,et al."A disease progression prediction model and nervous system symptoms in coronavirus disease 2019 patients".American Journal of Translational Research 12.12(2021):8192-8207.