Evaluation of thein vivobehavior of antibacterial gold nanoparticles for potential biomedical applications

Wang，Le1,2; Li，Sixiang2; Zhong，Leni2; Li，Qizhen2; Liu，Shaoqin1; Zheng，Wenfu3; Jiang，Xingyu2

2021-04-07

10.1039/d1tb00128k

Journal of Materials Chemistry B   影响因子和分区

2050-750X

2050-7518

The pharmacokinetics is a critical factor determining the clinical applicability of nanomaterials. Systematic study of the pharmacokinetics of functional nanomaterials is thus significant for promoting their applications. Herein, we take aminophenylboronic acid and mercaptophenylboronic acid-co-modified gold nanoparticles (A/M-Au NPs) with potent and tunable antibacterial activity as an example to study their behaviorsin vitroandin vivo. The maximum concentration (C, 2 mg L), the time to reach the maximum concentration (T, 6 h), and the half-life (T, 12 h) in the plasma of mice reflect appropriate pharmacokinetics of the gold nanoparticles as an ideal nano-antibiotic. Strikingly, the A/M-Au NPs show an extremely high median lethal dose (920 mg kg), which is about 100 times their effective dose (7.2 mg kg), suggesting their outstanding biosafety. The adequate pharmacokinetic profile and the high biosafety of the gold nanoparticles pave the way for their potential biomedical applications.

SCI ; EI

英语

其他

Shenzhen Science and Technology Program[KQTD20190929172743294] ; National Natural Science Foundation of China[21535001,81730051,81673039,32071390] ; National Key R&D Program of China[2018YFA0902600] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026"] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191]

Materials Science

Materials Science, Biomaterials

WOS:000631754800001

ROYAL SOC CHEMISTRY

20211510208657

Biohazards ; Fiber optic sensors ; Mammals ; Medical applications ; Metal nanoparticles ; Nanostructured materials ; Pharmacokinetics

Medicine and Pharmacology:461.6 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Accidents and Accident Prevention:914.1

2-s2.0-85103898788

Scopus

1.School of Life Science and Technology,Harbin Institute of Technology,Harbin,2 Yikuang Road, Nangang District,150001,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District,518055,China
3.GBA National Institute for Nanotechnology Innovation,CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety,National Center for NanoScience and Technology,Beijing,100190,China

Wang，Le,Li，Sixiang,Zhong，Leni,et al. Evaluation of thein vivobehavior of antibacterial gold nanoparticles for potential biomedical applications[J]. Journal of Materials Chemistry B,2021,9(13):3025-3031.

Wang，Le.,Li，Sixiang.,Zhong，Leni.,Li，Qizhen.,Liu，Shaoqin.,...&Jiang，Xingyu.(2021).Evaluation of thein vivobehavior of antibacterial gold nanoparticles for potential biomedical applications.Journal of Materials Chemistry B,9(13),3025-3031.

Wang，Le,et al."Evaluation of thein vivobehavior of antibacterial gold nanoparticles for potential biomedical applications".Journal of Materials Chemistry B 9.13(2021):3025-3031.