Low levels of BRCA1 protein expression predict a worse prognosis in stage I-II colon cancer.

Changzheng Du1,2; Yifan Peng3; Yiping He4,5; Guoan Chen1; Hao Chen1

2021-02

10.1177/1724600820986572

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS   影响因子和分区

0393-6155

1724-6008

Background: BRCA1 and BRCA2 have been well studied for their roles in tumorigeneis, plus cancer diagnosis and treatment, but their prognostic value in colon cancer, especially for early-stage cancer, has not been fully illuminated. This study examined the expression levels of BRCA1 and BRCA2 proteins in sporadic colon cancer cases and investigated their value in prognosis.

Methods: The expression levels of BRCA1 and BRCA2 in 275 colon cancer patients who underwent radical surgeries were assayed by immunohistochemical staining in dissected tumor samples. Also, its correlation with clinicopathological characteristics, disease-free survival, and overall survival was investigated.

Results: Tumors with low expression levels of BRCA1, BRCA2, and both were 19.6%, 17.8%, and 6.5%, respectively. The levels of BRCA1/2 expression were not associated with clinicopathological parameters (gender, age, histological differentiation, and tumor node metastasis stage). Patients with low-levels of BRCA1 protein in their tumors demonstrated a lower chance of 5-year disease-free survival (55.6% vs. 69.7%, P=0.046), which was more obvious in the patients with stage I-II tumors without chemotherapy (52.6% vs. 82.6%, P=0.006). Neither BRCA1 nor BRCA2 affected overall survival in this cohort. Multivariate analysis revealed that pathologic stage and the level of BRCA1 protein were independent factors of long-term disease-free survival.

Biomarker Colon Cancer Prognosis

SCI

英语

第一 ; 通讯

Southern University of Science and Technology[Y01416218]

Biotechnology & Applied Microbiology ; Oncology

Biotechnology & Applied Microbiology ; Oncology

WOS:000631230300001

SAGE PUBLICATIONS LTD

CLINICAL MEDICINE

人工提交

1.School of Medicine, the Southern University of Science and Technology, Shenzhen, Guangdong, People's Republic of China.
2.Southern University of Science and Technology Hospital, Shenzhen, Guangdong, People's Republic of China.
3.Gastrointestinal Cancer Center, Beijing Cancer Hospital, Beijing, People's Republic of China.
4.The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.
5.Department of Pathology, Duke University Medical Center, Durham, NC, USA.

Changzheng Du,Yifan Peng,Yiping He,et al. Low levels of BRCA1 protein expression predict a worse prognosis in stage I-II colon cancer.[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2021,36(1):47-53.

Changzheng Du,Yifan Peng,Yiping He,Guoan Chen,&Hao Chen.(2021).Low levels of BRCA1 protein expression predict a worse prognosis in stage I-II colon cancer..INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,36(1),47-53.

Changzheng Du,et al."Low levels of BRCA1 protein expression predict a worse prognosis in stage I-II colon cancer.".INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS 36.1(2021):47-53.