南方科技大学知识苑(SUSTech KC): Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation

题名	Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation
作者	Jinmei,Wang 1,2,3; Xiaoxiao,Wang2,4,5 ; Jundong,Xie 2,3,4; Bin,Yao 2,3,4; Miaohua,Mo 2,3,4; Danjun,Ma 1; Chen,Huang 6; Renhe,Xu 7; Xiaobing,Fu 8,9; Edward E.,Tredget 10; Yaojiong,Wu 2,3,4
通讯作者	Edward E.,Tredget; Yaojiong,Wu
共同第一作者	Jinmei,Wang; Xiaoxiao,Wang; Jundong,Xie
发表日期	2021-04-08
DOI	10.3390/biomedicines9040400
发表期刊	Biomedicines 影响因子和分区
ISSN	2227-9059
卷号	9 期号:4页码:400
摘要	Currently, engineered skin substitutes (ESS) are unable to regenerate cutaneous appendages. Recent studies have shown that skin-derived precursors (SKPs), which are extensively available, have the potential to induce hair follicle neogenesis. Here, we demonstrate that ESS consisting of culture-expanded SKPs and epidermal stem cells (Epi-SCs) reconstitute the skin with hair follicle regeneration after grafting into nude mice. SKPs seeded in a C-GAG matrix proliferated and expressed higher levels of hair induction signature genes—such as Akp2, Sox2, CD133 and Bmp6—compared to dermal fibroblasts. Moreover, when ESS prepared by seeding a mixture of culture-expanded murine SKPs and human adult Epi-SCs into a C-GAG matrix was grafted into full-thickness skin wounds in nude mice, black hairs were generated within 3 weeks. Immunofluorescence analysis showed that the SKPs were localized to the dermal papillae of the newly-formed hair follicle. Our results indicate that SKPs can serve as the hair-inductive cells in ESS to furnish it with hair genesis potential
关键词	Skin Derived Precursors Hair Follicle Neogenesis Engineered Skin Substitute
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	共同第一 ; 其他
WOS记录号	WOS:000642800700001
出版者	MDPI AG
来源库	人工提交
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/223985
专题	生命科学学院_生物系生命科学学院南方科技大学医学院
作者单位	1.School of Mechanical Engineering, Dongguan University of Technology, 1 Daxue Rd, Dongguan 523830, China 2.iBHE, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China; 3.State Key Laboratory of Chemical Oncogenomics, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China 4.Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen 518055, China 5.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China 6.Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University 7.Faculty of Health Sciences, University of Macau, Macau 999078, China; 8.Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing 100088, China 9.Stem Cell and Tissue Regeneration Laboratory, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100084, China 10.Wound Healing Research Group, Department of Surgery, University of Alberta, Edmonton, AB T6G2B7, Canada
推荐引用方式 GB/T 7714	Jinmei,Wang,Xiaoxiao,Wang,Jundong,Xie,et al. Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation[J]. Biomedicines,2021,9(4):400.
APA	Jinmei,Wang.,Xiaoxiao,Wang.,Jundong,Xie.,Bin,Yao.,Miaohua,Mo.,...&Yaojiong,Wu.(2021).Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation.Biomedicines,9(4),400.
MLA	Jinmei,Wang,et al."Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation".Biomedicines 9.4(2021):400.