| 题名 | Molecular biology of BPIFB1 and its advances in disease |
| 作者 | |
| 通讯作者 | Li, Jie |
| 发表日期 | 2020-05-01
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| DOI | |
| 发表期刊 | |
| ISSN | 2305-5839
|
| EISSN | 2305-5847
|
| 卷号 | 8期号:10 |
| 摘要 | Bactericidal/permeability-increasing (BPI)-fold-containing family B member 1 (BPIFB1), also known as long-palate lung and nasal epithelium clone 1 (LPLUNC1), belongs to the BPI-fold-containing family, is a newly discovered natural immune protection molecule, which, having the function of bactericidal and osmotic enhancement protein domain, can respond to the external physical and chemical stimuli. The gene of BPIFB1 is located at chromosome 20q11.21-20q11.22, and contains 16 exons and 15 introns, encoding 484 amino acids. The 5' terminal of the BPIFB1 protein has a signal peptide sequence composed of 19 amino acids. BPIFB1 is abnormally expressed in nasopharyngeal carcinoma (NPC), gastric cancer, and other cancer tissues, regulate chronic infections and inflammation, indicating that it may play an important role in the development of tumors. Meanwhile, BPIFB1 has well-recognized roles in sensing and responding to Gram-negative bacteria due to its structural similarity with BPI protein and lipopolysaccharide (LPS)-binding protein, both of which are innate immune molecules with recognized roles in sensing and responding to Gram-negative bacteria, so it can regulate cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma, and other respiratory diseases. In this article, we will discuss the progress of BPIFB1 in a variety of diseases and fully understand its function. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
; 通讯
|
| 资助项目 | National Natural Science Foundation of China[81770028]
|
| WOS研究方向 | Oncology
; Research & Experimental Medicine
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| WOS类目 | Oncology
; Medicine, Research & Experimental
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| WOS记录号 | WOS:000538022300041
|
| 出版者 | |
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：20
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/225073 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | Jinan Univ, Clin Med Coll 2,Shenzhen Peoples Hosp, Southern Univ Sci & Technol,Affiliated Hosp 1, Key Lab Shenzhen Resp Dis,Shenzhen Inst Resp Dis, Shenzhen, Peoples R China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Li, Jie,Xu, Peng,Wang, Lingvvei,et al. Molecular biology of BPIFB1 and its advances in disease[J]. Annals of Translational Medicine,2020,8(10).
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| APA |
Li, Jie.,Xu, Peng.,Wang, Lingvvei.,Feng, Mengjie.,Chen, Dandan.,...&Lu, Yongzhen.(2020).Molecular biology of BPIFB1 and its advances in disease.Annals of Translational Medicine,8(10).
|
| MLA |
Li, Jie,et al."Molecular biology of BPIFB1 and its advances in disease".Annals of Translational Medicine 8.10(2020).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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