南方科技大学知识苑(SUSTech KC): Enhancement of Osteogenic Induction by LL37 Modified with a Collagen-Binding Domain In Vitro and In Vivo

题名	Enhancement of Osteogenic Induction by LL37 Modified with a Collagen-Binding Domain In Vitro and In Vivo
作者	Lin, Xiaoxuan 1; Chen, Sipeng 1; Quan, Jingjing 1; Zhang, Qi 1; Liao, Muzi 1; Ma, Xinyue 1; Zheng, Yuyan 2; Mai, Sui 1
通讯作者	Mai, Sui
发表日期	2021-04-01
DOI	10.1007/s10989-021-10216-w
发表期刊	International Journal of Peptide Research and Therapeutics 影响因子和分区
ISSN	1573-3149
EISSN	1573-3904
摘要	Bone defect diseases, particularly those induced by inflammation, pose a challenge for the design of ideal drug-loading scaffolds that could facilitate bone repair and eliminate inflammatory pathogens. Antimicrobial peptides LL37 is considered a promising alternative loading drug due to its broad-spectrum antimicrobial effect and various bio-functions, including osteogenic induction. In this study, we synthesized modified LL37 by adding a collagen-binding domain (CBD) to achieve specific binding to collagen and a slow release pattern. The modified peptide was indicated to exhibit similar biological activities as natural LL37 on rat BMSCs, including promotion of migration activity, anti-inflammatory activity and osteogenic induction in vitro. Ectopic bone formation experiments further confirmed the angiogenesis and osteoinduction activities in vivo. Collectively, the results indicate that LL37-CBD may be a potential loading drug for preventative and curative applications in the treatment of inflammation-induced bone diseases.
关键词	LL37 Collagen-binding domain Osteoinduction
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	National Natural Science Foundation of China[82071162] ; Natural Science Foundation of Guangdong Province[2018B030311040] ; Guangdong Financial Fund for High-Caliber Hospital Construction[174-2018-XMZC-0001-03-0125/D-15]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000640833800001
出版者	SPRINGER
来源库	Web of Science
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/225086
专题	南方科技大学第一附属医院
作者单位	1.Sun Yat Sen Univ, Guanghua Sch Stomatol, Hosp Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Stomatol,Shenzhen Peoples Hosp,Sch Clin Med, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Lin, Xiaoxuan,Chen, Sipeng,Quan, Jingjing,et al. Enhancement of Osteogenic Induction by LL37 Modified with a Collagen-Binding Domain In Vitro and In Vivo[J]. International Journal of Peptide Research and Therapeutics,2021.
APA	Lin, Xiaoxuan.,Chen, Sipeng.,Quan, Jingjing.,Zhang, Qi.,Liao, Muzi.,...&Mai, Sui.(2021).Enhancement of Osteogenic Induction by LL37 Modified with a Collagen-Binding Domain In Vitro and In Vivo.International Journal of Peptide Research and Therapeutics.
MLA	Lin, Xiaoxuan,et al."Enhancement of Osteogenic Induction by LL37 Modified with a Collagen-Binding Domain In Vitro and In Vivo".International Journal of Peptide Research and Therapeutics (2021).