High population-attributable fractions of traditional risk factors for non-AIDS-defining diseases among people living with HIV in China: a cohort study

Liu, Jiaye1,2,3,4; Hou, Yuying3,4; Sun, Liqin1,2; Wang, Lifeng4; He, Yun1,2; Zhou, Yang1,2; Xu, Liumei1,2; Liu, Xiaoning1,2; Zhao, Fang1,2; Zhang, Lukun1,2; Wang, Hui1,2; Wang, Fu-Sheng3,4

2021

10.1080/22221751.2021.1894904

EMERGING MICROBES & INFECTIONS   影响因子和分区

2222-1751

Morbidity and mortality of non-AIDS-defining diseases (NADs) have become the increasing burden of people living with HIV (PLWH) with long-term antiretroviral therapy (ART). We aimed to quantify the contribution of modifiable risk factors to NADs. We included PLWHs starting ART at the Third People's Hospital of Shenzhen (China) from Jan 1, 2010 to Dec 31, 2017. We defined NAD outcomes of interest as cardiovascular disease (CVD), end-stage liver disease (ESLD), advanced renal disease (ARD), and non-AIDS-defining cancers (NADCs). We estimated incidence of outcomes and population-attributable fractions (PAFs) of modifiable traditional and HIV-related risk factors for each outcome. Overall, 8,301 participants (median age at study entry, 31 years) contributed 33,146 person-years of follow-up (PYFU). Incidence of CVD (362/100,000 PYFU) was the highest among outcomes, followed by that of ARD (270/100,000 PYFU), ESLD (213/100,000 PYFU), and NADC (152/100,000 PYFU). Totally, 34.14% of CVD was attributable to smoking, 7.98% to hypertension, and 6.44% to diabetes. For ESLD, 24.57% and 25.04% of it could be avoided if chronic hepatitis B and C virus infection, respectively, did not present. The leading PAFs for ARD were declined estimated glomerular filtration rate (eGFR) (39.68%) and low CD4 count (39.61%), followed by diabetes (10.19%). PAFs of hypertension, diabetes, and smoking for CVD, and declined eGFR and diabetes for ARD increased with age. The contribution of traditional risk factors for these NADs far outweighed the HIV-related risk factors. Individual-level interventions and population-level policy-making is needed to focus on these factors to prevent NADs in long-term management of HIV infection.

Human immunodeficiency virus AIDS incidence population attributable fraction non-AIDS-defining diseases

SCI

英语

第一 ; 通讯

China Postdoctoral Science Foundation[2019M660840] ; Sanming Project of Medicine in Shenzhen[SZSM201612014]

Immunology ; Infectious Diseases ; Microbiology

Immunology ; Infectious Diseases ; Microbiology

WOS:000629568500001

TAYLOR & FRANCIS LTD

Web of Science

1.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Peoples Hosp Shenzhen 3, Shenzhen 518100, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen 518100, Guangdong, Peoples R China
3.Med Sch Chinese PLA, Beijing 100853, Peoples R China
4.Peoples Liberat Army Gen Hosp, Med Ctr 5, Treatment & Res Ctr Infect Dis, Beijing, Peoples R China

Liu, Jiaye,Hou, Yuying,Sun, Liqin,et al. High population-attributable fractions of traditional risk factors for non-AIDS-defining diseases among people living with HIV in China: a cohort study[J]. EMERGING MICROBES & INFECTIONS,2021,10(1).

Liu, Jiaye.,Hou, Yuying.,Sun, Liqin.,Wang, Lifeng.,He, Yun.,...&Wang, Fu-Sheng.(2021).High population-attributable fractions of traditional risk factors for non-AIDS-defining diseases among people living with HIV in China: a cohort study.EMERGING MICROBES & INFECTIONS,10(1).

Liu, Jiaye,et al."High population-attributable fractions of traditional risk factors for non-AIDS-defining diseases among people living with HIV in China: a cohort study".EMERGING MICROBES & INFECTIONS 10.1(2021).