EXPRESSION OF SOX9 IN ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGICAL CHARACTERISTICS AND PROGNOSIS

Hong, Yingcai1,2; Wang, Zheng1,2; Rao, Zhanpeng1,2; Wan, Jun1,2; Ling, Xie'an1,2; Xu, Zhenglei1,2,3

2021

10.19193/0393-6384_2021_1_29

Acta Medica Mediterranea   影响因子和分区

0393-6384

2283-9720

["Objective: We aim to explore the expression of SOX9 in adenocarcinoma tissue at the esophagogastric junction and its correlation with clinicopathological features and prognosis.","Methods: From January 2013 to May 2014, 114 samples of AEG tissues and 72 samples of normal paracancerous tissues at the surgical margin from the Department of Pathology at our hospital were collected. Using immunohistochemistry, we examined the esophagogastric junction adenocarcinoma (AEG) samples and compared their expression levels of human sex-determining region Y box protein 9 (SOX9) to SOX9 expression levels in adjacent cancer tissues. We further analyzed the correlation between SOX9 expression levels and clinicopathological characteristics and prognosis.","Results: The high expression rate of SOX9 in AEG tissues was 46.49% (53/114), which was significantly higher than the low expression rate of SOX9 in adjacent tissues- 8.33% (6/72). The expression of SOX9 was correlated with the Lauren classification, tumor invasion depth, lymph node metastasis, distant metastasis, and the TNM stage in patients with AEG (P<0.05). It was not related to the patients' sex, age, tumor location, or tumor diameter tissue differentiation (P>0.05). According to Kaplan-Meier analysis, the 5-year survival rate of patients with high SOX expression was 30.19% (16/53), which was significantly lower than the 5-year survival rate of patients with low SOX expression (54.10%; 33/61). COX multivariate analysis revealed that the degree of tissue differentiation, depth of infiltration, and distant metastasis were independent risk factors affecting the prognosis of patients with AEG.","Conclusion: SOX9 is highly expressed in AEG tissues. Its expression level is related to the occurrence, development, invasion, and metastasis of AE. While it affects the prognosis, SOX9 cannot be used as an independent risk factor for AEG patients."]

SOX9 esophagogastric junction adenocarcinoma clinicopathological features prognosis correlation

SCI

英语

通讯

Project at Shenzhen People's Hospital[SYKYPY2019118]

General & Internal Medicine

Medicine, General & Internal

WOS:000621776000029

CARBONE EDITORE

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Thorac Surg, Shenzhen 518020, Guangdong, Peoples R China
2.South Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Clin Sch 2,Shenzhen Peoples Hosp,Dept Gastroenter, Shenzhen 518020, Guangdong, Peoples R China

Hong, Yingcai,Wang, Zheng,Rao, Zhanpeng,et al. EXPRESSION OF SOX9 IN ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGICAL CHARACTERISTICS AND PROGNOSIS[J]. Acta Medica Mediterranea,2021,37(1).

Hong, Yingcai,Wang, Zheng,Rao, Zhanpeng,Wan, Jun,Ling, Xie'an,&Xu, Zhenglei.(2021).EXPRESSION OF SOX9 IN ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGICAL CHARACTERISTICS AND PROGNOSIS.Acta Medica Mediterranea,37(1).

Hong, Yingcai,et al."EXPRESSION OF SOX9 IN ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGICAL CHARACTERISTICS AND PROGNOSIS".Acta Medica Mediterranea 37.1(2021).