A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology dagger

Xing, Yaru1,2; Liu, Yu2; Chen, Rifei2; Li, Yuyan3; Zhang, Chengzhi2; Jiang, Youwei2,4; Lu, Yao5; Lin, Bingcheng5; Chen, Peizhong6; Tian, Ruijun6; Liu, Xianming5; Cheng, Xing2

2021-03-01

10.1039/d1lc00101a

LAB ON A CHIP   影响因子和分区

1473-0197

1473-0189

Two-dimensional digital microfluidic platforms, on which droplets are actuated by electrowetting on dielectrics, have merits such as dynamic reconfigurability and ease for automation. However, concerns for digital microfluidic platforms based on low-cost printed circuit boards, such as the scalability of the electrode array and the reliability of the device operation, should be addressed before high throughput and fully automatic applications can be realized. In this work we report the progress in addressing those issues by using active-matrix circuitry to automatically drive a large electrode array with enhanced device reliability. We describe the design and the fabrication of a robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology. Reliable actuation of aqueous and organic droplets is achieved using a free-standing double-layer hydrophobic membrane. To demonstrate the versatility of the digital microfluidic platform, a pentapeptide is synthesized on the device within 30 minutes. With these improvements, a fully automatic, scalable, robust, reusable, and low-cost digital microfluidic platform capable of parallel manipulation of a large number of droplets can find numerous applications in chemical engineering, bioengineering and biomedical engineering.

SCI ; EI

英语

通讯

National Natural Science Foundation of China[31927802]

Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation

Biochemical Research Methods ; Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation

WOS:000637482300001

ROYAL SOC CHEMISTRY

20212110401521

Biomedical engineering ; Cost engineering ; Costs ; Drops ; Electrodes ; Printed circuit boards ; Printed circuit design ; Timing circuits

Biomedical Engineering:461.1 ; Microfluidics:632.5.1 ; Pulse Circuits:713.4 ; Cost and Value Engineering; Industrial Economics:911

CHEMISTRY

Web of Science

1.Harbin Inst Technol, Harbin 150001, Peoples R China
2.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Dept Elect & Elect Engn, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, SUSTech Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
6.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China

Xing, Yaru,Liu, Yu,Chen, Rifei,et al. A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology dagger[J]. LAB ON A CHIP,2021,21:1886-1896.

Xing, Yaru.,Liu, Yu.,Chen, Rifei.,Li, Yuyan.,Zhang, Chengzhi.,...&Cheng, Xing.(2021).A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology dagger.LAB ON A CHIP,21,1886-1896.

Xing, Yaru,et al."A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology dagger".LAB ON A CHIP 21(2021):1886-1896.