Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance

Liu, Yuantong1,2; Wang, Qinghe1; Zhang, Zengfu3; Fu, Runhan3; Zhou, Tianjian4; Long, Canling1; He, Tongzhong1; Yang, Dazhi1; Li, Zhizhong2; Peng, Songlin1,4

2021-05-01

10.1016/j.bone.2021.115886

BONE   影响因子和分区

8756-3282

1873-2763

Magnesium (Mg2+), as an essential mineral, supports and sustains the health and activity of the organs of the human body. Despite some clinical evidence on the association of Mg2+ deficiency with muscle regeneration dysfunction and sarcopenia in older-aged individuals, there is no consensus on the action mode and molecular mechanism by which Mg2+ influences aged muscle size and function. Here, we identified the appropriate Mg2+ environment that promotes the myogenic differentiation and myotube hypertrophy in both C2C12 myoblast and primary aged muscle stem cell (MuSC). Through animal experiments, we demonstrated that Mg2+ supplementation in aged mice significantly promotes muscle regeneration and conserves muscle mass and strength. Mechanistically, Mg2+ stimulation activated the mammalian target of rapamycin (mTOR) signalling, inducing the myogenic differentiation and protein synthesis, which consequently offers protections against the age-related decline in muscle regenerative potential and muscle mass. These findings collectively provide a promising therapeutic strategy for MuSC dysfunction and sarcopenia through Mg2+ supplementation in the elderly.

Magnesium Aging Muscle stem cell Myogenic differentiation Muscle regeneration Sarcopenia

SCI

英语

通讯

Science and Technology Innovation Commission of Shenzhen Municipality, China["JCYJ2018030 5164659637","JCYJ20190806160407178","JSGG20180504170427135","SGLH20180625141602256","JCYJ20180305164544288","JCYJ201704 1362104773"]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000634790200004

ELSEVIER SCIENCE INC

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Spine Surg, 1017 Dongmen Bei Rd, Shenzhen 518020, Peoples R China
2.Jinan Univ, Affiliated Hosp 1, 613 West Huangpu Ave, Guangzhou 510630, Peoples R China
3.Shandong Univ, Cheeloo Coll Med, Sch Med, Jinan 250012, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Key Lab Tissue & Funct Reconstruct Sport, Shenzhen 518020, Peoples R China

Liu, Yuantong,Wang, Qinghe,Zhang, Zengfu,et al. Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance[J]. BONE,2021,146.

Liu, Yuantong.,Wang, Qinghe.,Zhang, Zengfu.,Fu, Runhan.,Zhou, Tianjian.,...&Peng, Songlin.(2021).Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance.BONE,146.

Liu, Yuantong,et al."Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance".BONE 146(2021).