Long-term prognosis analysis of PARACHUTE device implantation in patients with ischemic heart failure: a single-center experience of Chinese patients

Li，Jianghua1,2; Liu，Huadong1,2; Liu，Qiyun1,2; Liu，Cheng1,2; Xiong，Wei1,2; Ma，Wei3; Zhang，Baowei3; Dong，Shaohong1,2,4; Li，Tangzhiming1,2,4

2021-12-01

10.1186/s13019-021-01484-0

Journal of Cardiothoracic Surgery   影响因子和分区

1749-8090

Background: Heart failure (HF) is one of the leading causes of mortality and morbidity. The PARACHUTE device is designed to partition for left ventricular (LV) apical aneurysm post extensive anterior myocardial infarction (MI). However, the long-term prognosis of the PARACHUTE device post-implantation is unclear. Methods: From November 2015 to April 2017, six subjects with New York Heart Association Classes II, III and IV ischemic HF, LV ejection fraction between (LVEF) 15 and 40%; and LV anterior apical aneurysm were enrolled in our center. The cumulative event rates for MI, hospitalization, and mortality were documented. Further assessment of LVEF, LV end-diastolic diameter (LVEDD), and estimated pulmonary artery pressure were determined by echocardiography core laboratory. For quantitative data comparison, paired t-test was employed. Results: Device implantation was successful in all six enrolled subjects, and acute device association adverse events were not observed. At 4.6 ± 1.7 years follow-up, major adverse cardiac events (MACEs) were found in 50% patients, and the survival rate was 86.7%. We observed that the LVEF was significantly elevated after deployment (46.00 ± 6.00% vs. 35.83 ± 1.47%, P = 0.009). Besides, the LVEDD elevated after MI (51.17 ± 3.71 vs. 62.83 ± 3.25, P < 0.001) was revealed, but the device sustained preserved LVEDD after implantation. Conclusion: The PARACHUTE device is an alternative therapy for patients with severe LV maladaptive remodeling. However, the device seems to increase the HF ratio. Trial registration: NCT02240940

Heart failure Left ventricular systolic function Mortality Myocardial infarction

SCI

英语

通讯

Medical Scientific Research Foundation of Guangdong Province of China[A2018530] ; Sanming Project of Medicine in Shenzhen[SZSM201412012] ; Shenzhen Key Medical Discipline Construction Fund[szxk003] ; Science and Technology Planning Project of Shenzhen Municipality[JCYJ20170307100512856] ; National Natural Science Foundation of China[81770496]

Cardiovascular System & Cardiology ; Surgery

Cardiac & Cardiovascular Systems ; Surgery

WOS:000642565900004

BMC

2-s2.0-85104577007

Scopus

1.Department of Cardiology,Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center,Shenzhen People’s Hospital,Shenzhen,518020,China
2.The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
3.Department of Cardiovascular Disease,Peking University First Hospital,Beijing,100034,China
4.Department of Cardiology,Shenzhen People’s Hospital,Shenzhen,1017 Dongmen North Road,China

Li，Jianghua,Liu，Huadong,Liu，Qiyun,et al. Long-term prognosis analysis of PARACHUTE device implantation in patients with ischemic heart failure: a single-center experience of Chinese patients[J]. Journal of Cardiothoracic Surgery,2021,16(1).

Li，Jianghua.,Liu，Huadong.,Liu，Qiyun.,Liu，Cheng.,Xiong，Wei.,...&Li，Tangzhiming.(2021).Long-term prognosis analysis of PARACHUTE device implantation in patients with ischemic heart failure: a single-center experience of Chinese patients.Journal of Cardiothoracic Surgery,16(1).

Li，Jianghua,et al."Long-term prognosis analysis of PARACHUTE device implantation in patients with ischemic heart failure: a single-center experience of Chinese patients".Journal of Cardiothoracic Surgery 16.1(2021).