Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus

Wang，Gang1; Guan，Jun1; Khan，Nazif U.1; Li，Guojun2,3; Shao，Junwei1; Zhou，Qihui1; Xu，Lichen1; Huang，Chunhong1; Deng，Jingwen1; Zhu，Haihong1; Chen，Zhi1

2021-12-01

10.1186/s13099-021-00421-9

Gut Pathogens   影响因子和分区

1757-4749

Interferon-alpha (IFN-α) and nucleot(s)ide analogs (NAs) are first-line drugs for the treatment of chronic hepatitis B virus (HBV) infections. Generally, NAs target the reverse transcription of HBV pregenomic RNA, but they cannot eliminate covalently-closed-circular DNA (cccDNA). Although effective treatment with NAs can dramatically decrease HBV proteins and DNA loads, and even promote serological conversion, cccDNA persists in the nucleus of hepatocytes due to the lack of effective anti-cccDNA drugs. Of the medications currently available, only IFN-α can potentially target cccDNA. However, the clinical effects of eradicating cccDNA using IFN-α in the hepatocytes of patients with HBV are not proficient as well as expected and are not well understood. Herein, we review the anti-HBV mechanisms of IFN-α involving cccDNA modification as the most promising approaches to cure HBV infection. We expect to find indications of promising areas of research that require further study to eliminate cccDNA of HBV in patients.

Chronic HBV infection Covalently closed circular DNA (cccDNA) Deamination Hepatitis B virus interferon-α

SCI

英语

其他

WOS:000639446200001

2-s2.0-85104261322

Scopus

1.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,National Clinical Research Center for Infectious Diseases,Zhejiang University School of Medicine,Hangzhou,79 Qingchun Road,310003,China
2.Institute for Hepatology,Shenzhen Third People’s Hospital,National Clinical Research Center for Infectious Disease,Shenzhen,518112,China
3.The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,518112,China

Wang，Gang,Guan，Jun,Khan，Nazif U.,et al. Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus[J]. Gut Pathogens,2021,13(1).

Wang，Gang.,Guan，Jun.,Khan，Nazif U..,Li，Guojun.,Shao，Junwei.,...&Chen，Zhi.(2021).Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus.Gut Pathogens,13(1).

Wang，Gang,et al."Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus".Gut Pathogens 13.1(2021).