南方科技大学知识苑(SUSTech KC): MiR-139-5p Regulates the Proliferation of Acute Promyelocytic Leukemia Cells by Targeting MNT

题名	MiR-139-5p Regulates the Proliferation of Acute Promyelocytic Leukemia Cells by Targeting MNT
作者	Fu，Yueyue 1; Li，Limin 2; Hou，Jinxiao 1; Li，Huibo 1; Lv，Chengfang 2; Yu，Hongjuan 2; Zhang，Xiaoqian2 ; Xu，Mengyuan 2; Zhang，Mingwen 1; Meng，Hongbin 1; Liu，Jie 1; Lian，Xin 1; Feng，Jiawei 1; Zhou，Jin 1
通讯作者	Zhou，Jin
发表日期	2021
DOI	10.1155/2021/5522051
发表期刊	Journal of Oncology 影响因子和分区
ISSN	1687-8450
EISSN	1687-8469
卷号	2021
摘要	Acute promyelocytic leukemia (APL) patients with progressive leukocytosis are more likely to have various complications and poor outcomes. However, the regulatory roles of microRNAs in the leukocytosis of APL have not been clarified. Our study aims to evaluate the effects of miRNAs on leukocytosis during induction therapy of APL patients and explore its potential mechanisms. During induction treatment, patients with white blood cell count higher than 10 × 109/L were divided into leukocytosis group and others were nonleukocytosis group. Using microarray assays, we found that miR-139-5p was significantly downregulated in the leukocytosis group. Elevated expression of miR-139-5p inhibited the proliferation of NB4 cells by arresting the cell cycle and inducing apoptosis. We further identified that MNT was a target of miR-139-5p. miR-139-5p significantly inhibited the proliferation, invasion, and migration function of NB4 cells through targeting MNT. Strategies for regulating miR-139-5p or MNT expression might provide new therapeutic approaches for progressive leukocytosis in APL.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS记录号	WOS:000663249100001
Scopus记录号	2-s2.0-85104926010
来源库	Scopus
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/227808
专题	南方科技大学南方科技大学医院
作者单位	1.Department of Hematology,First Affiliated Hospital,Harbin Medical University,Harbin, Heilongjiang,150001,China 2.Department of Hematology,South University of Science and Technology Hospital,Shenzhen,China
推荐引用方式 GB/T 7714	Fu，Yueyue,Li，Limin,Hou，Jinxiao,et al. MiR-139-5p Regulates the Proliferation of Acute Promyelocytic Leukemia Cells by Targeting MNT[J]. Journal of Oncology,2021,2021.
APA	Fu，Yueyue.,Li，Limin.,Hou，Jinxiao.,Li，Huibo.,Lv，Chengfang.,...&Zhou，Jin.(2021).MiR-139-5p Regulates the Proliferation of Acute Promyelocytic Leukemia Cells by Targeting MNT.Journal of Oncology,2021.
MLA	Fu，Yueyue,et al."MiR-139-5p Regulates the Proliferation of Acute Promyelocytic Leukemia Cells by Targeting MNT".Journal of Oncology 2021(2021).