南方科技大学知识苑(SUSTech KC): Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study

题名	Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study
作者	Chen，Shuyan; Zhu，Qing; Xiao，Yanyu; Wu，Chi; Jiang，Zhaofang; Liu，Lei; Qu，Jiuxin
通讯作者	Qu，Jiuxin
发表日期	2021
DOI	10.1111/crj.13369
发表期刊	Clinical Respiratory Journal 影响因子和分区
ISSN	1752-6981
EISSN	1752-699X
摘要	Background: Co-infections, secondary bacterial or fungal infections, are important risk factors for poor outcomes in viral infections. The prevalence of co-infection and secondary infection in patients infected with SARS-CoV-2 is not well understood. Aims: To investigate the role of co-infections and secondary infections in disease severity of hospitalized individuals with COVID-19. Materials and Methods: A retrospective study was carried out between 11 January 2020 and 1 March 2020 among 408 laboratory confirmed COVID-19 patients in China. These patients were divided into three groups based on disease severity: mild or moderate, severe, or critically ill. Microbiological pathogens in blood, urine, and respiratory tract specimens were detected by the combination of culture, serology, polymerase chain reaction, and metagenomic next-generation sequencing (mNGS). Results: The median age of participants was 48 years (IQR 34–60 years). Fifty-two patients (12.7%) had at least one additional pathogen, 8.1% were co-infected, and 5.1% had a secondary infection. There were 13 Mycoplasma pneumoniae cases, 8 Haemophilus influenzae cases, 8 respiratory viruses, and 3 Streptococcus pneumoniae cases, primarily detected in mild and moderate COVID-19 patients. Hospital-acquired infection pathogens were more common in critically ill patients. Compared to those without additional pathogens, patients with co-infections and/or secondary infections were more likely to receive antibiotics (p < 0.001) and have elevated levels of d-dimer (p = 0.0012), interleukin-6 (p = 0.0027), and procalcitonin (p = 0.0002). The performance of conventional culture was comparable with that of mNGS in diagnosis of secondary infections. Conclusion: Co-infections and secondary infections existed in hospitalized COVID-19 patients and were relevant to the disease severity. Screening of common respiratory pathogens and hospital infection control should be strengthened.
关键词	co-infection COVID-19 etiology mNGS secondary infection
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
WOS研究方向	Respiratory System
WOS类目	Respiratory System
WOS记录号	WOS:000641054700001
出版者	WILEY
Scopus记录号	2-s2.0-85104428804
来源库	Scopus
引用统计	被引频次[WOS]：36
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/227829
专题	南方科技大学第二附属医院
作者单位	Department of Clinical Laboratory,Shenzhen Third People's Hospital,Southern University of Science and Technology,National Clinical Research Center for Infectious Diseases,Shenzhen,China
第一作者单位	南方科技大学第二附属医院
通讯作者单位	南方科技大学第二附属医院
第一作者的第一单位	南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Chen，Shuyan,Zhu，Qing,Xiao，Yanyu,et al. Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study[J]. Clinical Respiratory Journal,2021.
APA	Chen，Shuyan.,Zhu，Qing.,Xiao，Yanyu.,Wu，Chi.,Jiang，Zhaofang.,...&Qu，Jiuxin.(2021).Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study.Clinical Respiratory Journal.
MLA	Chen，Shuyan,et al."Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study".Clinical Respiratory Journal (2021).