| 题名 | The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy |
| 作者 | |
| 通讯作者 | Li, Xiao-Feng |
| 发表日期 | 2021-04-19
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| DOI | |
| 发表期刊 | |
| ISSN | 1663-9812
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| 卷号 | 12 |
| 摘要 | Hypoxia is an important feature of most solid tumors, conferring resistance to radiation and many forms of chemotherapy. However, it is possible to exploit the presence of tumor hypoxia with hypoxia-activated prodrugs (HAPs), agents that in low oxygen conditions undergo bioreduction to yield cytotoxic metabolites. Although many such agents have been developed, we will focus here on TH-302. TH-302 has been extensively studied, and we discuss its mechanism of action, as well as its efficacy in preclinical and clinical studies, with the aim of identifying future research directions. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | Shenzhen Science and Technology Project[JCYJ20190806151003583]
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| WOS研究方向 | Pharmacology & Pharmacy
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| WOS类目 | Pharmacology & Pharmacy
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| WOS记录号 | WOS:000646247300001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：37
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/228159 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Nucl Med, Shenzhen, Peoples R China 2.Jinan Univ, Affiliated Hosp 1, Guangzhou, Peoples R China 3.Southern Univ Sci & Technol, Dept Nucl Med, Affiliated Hosp 1, Shenzhen, Peoples R China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Li, Yue,Zhao, Long,Li, Xiao-Feng. The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy[J]. Frontiers in Pharmacology,2021,12.
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| APA |
Li, Yue,Zhao, Long,&Li, Xiao-Feng.(2021).The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy.Frontiers in Pharmacology,12.
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| MLA |
Li, Yue,et al."The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy".Frontiers in Pharmacology 12(2021).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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