Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China

Wang, Jun1,2; Liu, Fangchao1; Li, Jianxin1; Huang, Keyong1; Yang, Xueli3,4; Chen, Jichun1; Liu, Xiaoqing5,6; Cao, Jie1; Chen, Shufeng1; Shen, Chong7; Yu, Ling8; Lu, Fanghong9; Wu, Xianping10; Zhao, Liancheng1; Li, Ying1; Hu, Dongsheng11,12; Huang, Jianfeng1; Gu, Dongfeng1,2,13; Lu, Xiangfeng1,2

2021-04-01

10.1007/s11427-020-1896-x

Science China-Life Sciences   影响因子和分区

1674-7305

1869-1889

Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease (CVD) and all-cause mortality was inconsistent. These associations were examined using a large-scale, population-based Chinese cohort comprising 100,728 participants. A food-frequency questionnaire was used to assess fruit and vegetable consumption. Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates. Cox proportional hazards regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). At the 736,668 person-years of follow-up, 3,677 CVD cases and 5,466 deaths were identified. The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1 (reference), 0.94 (95%CI=0.85-1.04), 0.89 (95%CI=0.80-0.98), and 0.85 (95% CI=0.11-0.95). Moreover, participants in the highest quartile displayed a 13% lower risk of all-cause mortality (HR=0.81; 95% CI=0.80-0.95). A nonlinear dose-response relation was found for CVD, without additional benefits beyond a consumption of 600 g d(-1), whereas the all-cause mortality risk decreased along with higher consumption, with a linear trend. These associations remained significant for fruit consumption but not for vegetable consumption. Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all cause mortality. Increasing fruit and vegetable consumption, especially fruit, in the general population would prevent CVD and premature mortality.

fruit vegetable cardiovascular disease mortality

SCI

英语

其他

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences["2017-I2M-1-004","2019-I2M-2-003"] ; National Key Research and Development Program of China["2017YFC0211700","2018YFE0115300"] ; National Natural Science Foundation of China[91643208]

Life Sciences & Biomedicine - Other Topics

Biology

WOS:000643215100001

SCIENCE PRESS

Web of Science

1.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China
2.Chinese Acad Med Sci, Key Lab Cardiovasc Epidemiol, Beijing 100037, Peoples R China
3.Tianjin Med Univ, Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin 300070, Peoples R China
4.Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tianjin 300070, Peoples R China
5.Guangdong Prov Peoples Hosp, Div Epidemiol, Guangzhou 510080, Peoples R China
6.Cardiovasc Inst, Guangzhou 510080, Peoples R China
7.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 211166, Peoples R China
8.Fujian Prov Hosp, Dept Cardiol, Fuzhou 350014, Peoples R China
9.Shandong Acad Med Sci, Inst Basic Med, Cardiocerebrovasc Control & Res Ctr, Jinan 250062, Peoples R China
10.Sichuan Ctr Dis Control & Prevent, Chengdu 610041, Peoples R China
11.Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou 450001, Peoples R China
12.Shenzhen Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
13.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China

Wang, Jun,Liu, Fangchao,Li, Jianxin,et al. Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China[J]. Science China-Life Sciences,2021.

Wang, Jun.,Liu, Fangchao.,Li, Jianxin.,Huang, Keyong.,Yang, Xueli.,...&Lu, Xiangfeng.(2021).Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China.Science China-Life Sciences.

Wang, Jun,et al."Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China".Science China-Life Sciences (2021).