Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii

Luo，Tao1,2; Xu，Peng2,3; Zhang，Yangyi4; Porter，Jessica L.5,6; Ghanem，Marwan7; Liu，Qingyun2; Jiang，Yuan4; Li，Jing4; Miao，Qing8; Hu，Bijie8; Howden，Benjamin P.5,6,9; Fyfe，Janet A.M.10; Globan，Maria10; He，Wencong11; He，Ping11; Wang，Yiting11; Liu，Houming12; Takiff，Howard E.13,14,15; Zhao，Yanlin11; Chen，Xinchun16; Pan，Qichao4; Behr，Marcel A.7; Stinear，Timothy P.5,6; Gao，Qian2

2021-12-01

10.1038/s41467-021-22760-6

Nature Communications   影响因子和分区

2041-1723

Mycobacterium kansasii can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous mycobacteria known as the M. kansasii complex (MKC). Here, we report a population genomics analysis of 358 MKC isolates from worldwide water and clinical sources. We find that recombination, likely mediated by distributive conjugative transfer, has contributed to speciation and on-going diversification of the MKC. Our analyses support municipal water as a main source of MKC infections. Furthermore, nearly 80% of the MKC infections are due to closely-related M. kansasii strains, forming a main cluster that apparently originated in the 1900s and subsequently expanded globally. Bioinformatic analyses indicate that several genes involved in metabolism (e.g., maintenance of the methylcitrate cycle), ESX-I secretion, metal ion homeostasis and cell surface remodelling may have contributed to M. kansasii’s success and its ongoing adaptation to the human host.

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英语

NI期刊

其他

WOS:000656508100005

2-s2.0-85105331861

Scopus

1.Department of Pathogen Biology,West China School of Basic Medical Sciences & Forensic Medicine,Sichuan University,Chengdu,China
2.Shanghai Institute of Infectious Disease and Biosecurity,Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS),Shanghai Medical College and School of Basic Medical Sciences,Shanghai Public Health Clinical Center,Fudan University,Shanghai,China
3.Key Laboratory of Characteristic Infectious Disease & Bio-safety Development of Guizhou Province Education Department,Institute of Life Sciences,Zunyi Medical University,Zunyi,China
4.Department of Tuberculosis Control,Shanghai Municipal Centre for Disease Control and Prevention,Shanghai,China
5.Department of Microbiology and Immunology,Doherty Institute for Infection and Immunity,University of Melbourne,Melbourne,Australia
6.Doherty Applied Microbial Genomics,Doherty Institute for Infection and Immunity,University of Melbourne,Melbourne,Australia
7.Department of Microbiology and Immunology,McGill University and McGill International TB Centre,Montreal,Canada
8.Department of Infectious Diseases,Zhongshan Hospital,Fudan University,Shanghai,China
9.Microbiological Diagnostic Unit Public Health Laboratory,Doherty Institute for Infection and Immunity,University of Melbourne,Melbourne,3000,Australia
10.Victorian Infectious Diseases Reference Laboratory,Doherty Institute for Infection and Immunity,Melbourne Health,Melbourne,Australia
11.Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing,China
12.Department of Clinical Laboratory,The Third People’s Hospital of Shenzhen,Southern University of Science and Technology,Shenzhen,China
13.Unité de Pathogenetique Integrée Mycobacterienne,Institut Pasteur,Paris,France
14.Laboratorio de Genética Molecular,CMBC,IVIC,Caracas,Venezuela
15.Shenzhen Nanshan Center for Chronic Disease Control,Shenzhen,China
16.Guangdong Provincial Key Laboratory of Regional Immunity and Diseases,Department of Pathogen Biology,Shenzhen University School of Medicine,Shenzhen,China

Luo，Tao,Xu，Peng,Zhang，Yangyi,et al. Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii[J]. Nature Communications,2021,12(1).

Luo，Tao.,Xu，Peng.,Zhang，Yangyi.,Porter，Jessica L..,Ghanem，Marwan.,...&Gao，Qian.(2021).Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii.Nature Communications,12(1).

Luo，Tao,et al."Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii".Nature Communications 12.1(2021).