南方科技大学知识苑(SUSTech KC): Association of T lymphocytes level and clinical severity in patients of COVID-19 in Shenzhen China

题名	Association of T lymphocytes level and clinical severity in patients of COVID-19 in Shenzhen China
作者	Qiang，Wu; Chunxiao，Lu; Jiafeng，Wu; Xiaolong，Li; Fengxin，Wang; Hong，Gao; Lei，Liu
通讯作者	Hong，Gao
发表日期	2021
DOI	10.1177/20587392211014409
发表期刊	European Journal of Inflammation 影响因子和分区
ISSN	1721-727X
卷号	19
摘要	To explore the correlation between T lymphocytes and clinical severity in patients of COVID-19. A total of 183 COVID-19 patients were recruited in Shenzhen Third People’s Hospital from January 11 to February 16, 2020. According to the clinical classification criteria, they were divided into severe group (46 cases) and non-severe (137cases). T lymphocyte counts, lymphocyte subpopulation, IL-6 levels, and clinical outcomes were compared between the two groups. Compared with the non-severe group, the lymphocyte count, T lymphocyte count, T lymphocyte percentage, CD4 T lymphocyte count, CD4 T lymphocyte percentage, CD8 T lymphocyte count, and CD8 T lymphocyte percentage were lower in the severe group (p < 0.05). Compared with the non-severe group, IL-6 were higher in the severe group (p < 0.05). Compared with admission, the T lymphocyte count, CD4 T lymphocyte count, and CD8 T lymphocyte count were significantly increased upon discharge in severe patients, non-severe patients and all patients. Multivariate Logsitic regression analysis showed CD4 T lymphocyte count (OR −0.011; 95% CI −0.041 to −0.001; p = 0.011), CD8 T lymphocyte count (OR −0.14; 95% CI −0.048 to −0.003; p = 0.013) were closely correlated with the clinical severity in patients of COVID-19. Multivariate Logsitic regression analysis also showed CD4 T lymphocyte count (OR −0.012; 95% CI −3.177 to 0.261; p = 0.021), CD8 T lymphocyte count (OR −0.019; 95% CI −5.852 to 0.115; p = 0.004) were independent predictors of disease progressing to the composite endpoint. Subgroup analysis for critically ill patients: The T lymphocyte count, CD4 T lymphocyte count, and CD8 T lymphocyte count remained low in the death patients. The T lymphocyte count, CD4 T lymphocyte count, and CD8 T lymphocyte count recovered soon in the discharged patients. In the event of COVID-19 infection, the T-lymphoid system is the primary activated immune system. The T lymphocytes, CD4 T lymphocytes, CD8 T lymphocytes continued to be low may be significantly related to the deterioration of the disease, and may indicate a poor prognosis.
关键词	COVID-19 immunity inflammation T lymphocytes
相关链接	[Scopus记录]
语种	英语
学校署名	第一 ; 通讯
Scopus记录号	2-s2.0-85105872977
来源库	Scopus
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/228486
专题	南方科技大学第二附属医院
作者单位	Department of Cardiology,National Clinical Research Center for Infectious Disease,State Key Discipline of Infectious Disease,Shenzhen Third People’s Hospital,Second Hospital,Southern University of Science and Technology,Shenzhen,China
第一作者单位	南方科技大学第二附属医院
通讯作者单位	南方科技大学第二附属医院
第一作者的第一单位	南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Qiang，Wu,Chunxiao，Lu,Jiafeng，Wu,et al. Association of T lymphocytes level and clinical severity in patients of COVID-19 in Shenzhen China[J]. European Journal of Inflammation,2021,19.
APA	Qiang，Wu.,Chunxiao，Lu.,Jiafeng，Wu.,Xiaolong，Li.,Fengxin，Wang.,...&Lei，Liu.(2021).Association of T lymphocytes level and clinical severity in patients of COVID-19 in Shenzhen China.European Journal of Inflammation,19.
MLA	Qiang，Wu,et al."Association of T lymphocytes level and clinical severity in patients of COVID-19 in Shenzhen China".European Journal of Inflammation 19(2021).