Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population

Zhou，Yumin1; Wang，Man2; Yang，Weiyan2; Li，Jianjun2; Li，Jialin3; Hu，Yueying2; Wang，Wei2; Che，Chunli2; Qi，Hong4

2021

10.1155/2021/9953234

DISEASE MARKERS   影响因子和分区

0278-0240

1875-8630

Background. Chronic obstructive pulmonary disease (COPD) is a typical heterogeneous condition caused by environmental and genetic risk factors. Objectives. We investigated extrinsic (environmental) and intrinsic (genetic) factors contributing to the development of COPD in a nonsmoker road-working population in Northeast China. Method. The target population was divided into a COPD group and an exposed control group. Another healthy nonroad working nonsmoker control group was also included for environmental factor comparison. Peripheral blood was collected and analyzed using inductively coupled plasma mass spectrometry for inorganic elements of PM2.5, and microarray, rt-PCR, and Multiplex ELISA for genetic factors. Results. Forty-three COPD road workers, thirty-nine non-COPD road workers, and 52 age and gender-matched healthy nonroad workers were enrolled. There were significantly higher levels in all 24 inorganic elements in the COPD group compared with the healthy control group except potassium and manganese, while the majority of inorganic elements were similar between the COPD group and the exposed control group except in aluminum and cobalt. There were 39 genes showing significant differences between the COPD group and the exposed control group. Collagen, type XV, alpha 1 (COL15A1), Meis homeobox 1 (MEIS1), carbonyl reductase 3 (CBR3), and amine oxidase, copper containing 3 (AOC3) were confirmed by rt-PCR to be differentially expressed. Their correlations with blood cytokines were also evaluated. Conclusions. Aluminum might contribute to the development of COPD in the road-working population. CBR3 and AOC3 seem expressed in different patterns than previously reported, evidenced by their correlation with proinflammatory and anti-inflammatory cytokines.

SCI

英语

其他

WOS:000655045800002

CLINICAL MEDICINE

2-s2.0-85105757557

Scopus

1.State Key Laboratory of Respiratory Disease,National Center for Respiratory Diseases,Guangzhou Institute of Respiratory Diseases,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China
2.Harbin Medical University,Harbin,150010,China
3.Department of Respiratory Medicine,Southern University of Science and Technology Hospital,Shenzhen,518012,China
4.State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology,Harbin,150090,China

Zhou，Yumin,Wang，Man,Yang，Weiyan,et al. Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population[J]. DISEASE MARKERS,2021,2021.

Zhou，Yumin.,Wang，Man.,Yang，Weiyan.,Li，Jianjun.,Li，Jialin.,...&Qi，Hong.(2021).Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population.DISEASE MARKERS,2021.

Zhou，Yumin,et al."Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population".DISEASE MARKERS 2021(2021).