NO donors and NO delivery methods for controlling biofilms in chronic lung infections

Cai，Yu Ming1; Zhang，Ying Dan2; Yang，Liang2

2021

10.1007/s00253-021-11274-2

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY   影响因子和分区

0175-7598

1432-0614

Abstract: Nitric oxide (NO), the highly reactive radical gas, provides an attractive strategy in the control of microbial infections. NO not only exhibits bactericidal effect at high concentrations but also prevents bacterial attachment and disperses biofilms at low, nontoxic concentrations, rendering bacteria less tolerant to antibiotic treatment. The endogenously generated NO by airway epithelium in healthy populations significantly contributes to the eradication of invading pathogens. However, this pathway is often compromised in patients suffering from chronic lung infections where biofilms dominate. Thus, exogenous supplementation of NO is suggested to improve the therapeutic outcomes of these infectious diseases. Compared to previous reviews focusing on the mechanism of NO-mediated biofilm inhibition, this review explores the applications of NO for inhibiting biofilms in chronic lung infections. It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods. Key points: • The relationship between abnormal NO levels and biofilm development in lungs • The antibiofilm property of NO and current applications in lungs • Potential NO delivery methods and research directions in the future

Biofilm Chronic lung infection Nitric oxide Pseudomonas aeruginosa

SCI ; EI

英语

其他

WOS:000646162900009

20211910329383

Biological organs ; Nitric oxide ; Pulmonary diseases

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biomaterials (including synthetics):462.5 ; Inorganic Compounds:804.2

BIOLOGY & BIOCHEMISTRY

2-s2.0-85105404038

Scopus

1.Institute for Life Sciences,University of Southampton,Southampton,SO17 1BJ,United Kingdom
2.School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China

Cai，Yu Ming,Zhang，Ying Dan,Yang，Liang. NO donors and NO delivery methods for controlling biofilms in chronic lung infections[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2021,105:3931-3954.

Cai，Yu Ming,Zhang，Ying Dan,&Yang，Liang.(2021).NO donors and NO delivery methods for controlling biofilms in chronic lung infections.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,105,3931-3954.

Cai，Yu Ming,et al."NO donors and NO delivery methods for controlling biofilms in chronic lung infections".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 105(2021):3931-3954.