南方科技大学知识苑(SUSTech KC): 中国科学:化学（英文版）

题名	中国科学:化学（英文版）
作者	Jian Zhang 1 ; Yi-Yan Wang 3; He Sun4 ; Shao-Yu Li ; Shao-Hua Xiang ; Bin Tan
发表日期	2020
发表期刊	Science China-Chemistry 影响因子和分区
ISSN	1674-7291
卷号	63 期号:1页码:47-54
摘要	A catalytic enantioselective three-component Ugi reaction was developed.SPINOL-derived phosphoric acid with bulky 2,4,6-tricyclohexylphenyl groups at the 6,6'positions was found to be the best catalyst to afford αt-amino amide derivatives in good to excellent yields (62％ to 99％) and enantiocontrol (81％ to ＞99％ enantiomeric excess).This asymmetric reaction was applicable well to an array of aliphatic aldehydes.The gram-scale synthesis,modification ofdapsone,and enantioselective synthesis of(R)-Lacosamide underline the general utility of this methodology.Influence of dihedral angles and substituents of the chiral phosphoric acids on the enantioselectivity was also discussed in this article.
关键词	α-amino amide Ugi reaction chiral phosphoric acid enantioselectivity Lacosamide
相关链接	[万方记录]
语种	英语
学校署名	第一
资助项目	(This work was supported by the National Natural Science Foundation of China )%(Shenzhen Special Funds for the Development of Biomedicine,Internet,New Energy,and New Material Industries )%(Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation )
ESI学科分类	CHEMISTRY
来源库	WanFang
万方记录号	perioarticalzgkx-eb202001011
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/229195
专题	理学院_化学系前沿与交叉科学研究院深圳格拉布斯研究院
作者单位	1.School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China;Department of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen 518055, China 2.Department of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen 518055, China 3.Department of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen 518055, China;Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, China 4.南方科技大学
第一作者单位	化学系; 深圳格拉布斯研究院
第一作者的第一单位	化学系; 深圳格拉布斯研究院
推荐引用方式 GB/T 7714	Jian Zhang,Yi-Yan Wang,He Sun,等. 中国科学:化学（英文版）[J]. Science China-Chemistry,2020,63(1):47-54.
APA	Jian Zhang,Yi-Yan Wang,He Sun,Shao-Yu Li,Shao-Hua Xiang,&Bin Tan.(2020).中国科学:化学（英文版）.Science China-Chemistry,63(1),47-54.
MLA	Jian Zhang,et al."中国科学:化学（英文版）".Science China-Chemistry 63.1(2020):47-54.