Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling

Blackmore, Daniel G.1; Turpin, Fabrice2; Palliyaguru, Tishila1; Evans, Harrison T.1; Chicoteau, Antony1; Lee, Wendy1; Pelekanos, Matthew1; Nguyen, Nghia1; Song, Jae1; Sullivan, Robert K. P.2; Sah, Pankaj2,3,4; Bartlett, Perry F.1,2,3,4; Gotz, Jurgen1

2021-05-01

10.1038/s41380-021-01129-7

MOLECULAR PSYCHIATRY   影响因子和分区

1359-4184

1476-5578

Advanced physiological aging is associated with impaired cognitive performance and the inability to induce long-term potentiation (LTP), an electrophysiological correlate of memory. Here, we demonstrate in the physiologically aged, senescent mouse brain that scanning ultrasound combined with microbubbles (SUS+MB), by transiently opening the blood-brain barrier, fully restores LTP induction in the dentate gyrus of the hippocampus. Intriguingly, SUS treatment without microbubbles (SUSonly), i.e., without the uptake of blood-borne factors, proved even more effective, not only restoring LTP, but also ameliorating the spatial learning deficits of the aged mice. This functional improvement is accompanied by an altered milieu of the aged hippocampus, including a lower density of perineuronal nets, increased neurogenesis, and synaptic signaling, which collectively results in improved spatial learning. We therefore conclude that therapeutic ultrasound is a non-invasive, pleiotropic modality that may enhance cognition in elderly humans.

SCI

英语

NI论文

其他

National Health and Medical Research Council of Australia["GNT1145580","GNT1176326"]

Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry

Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry

WOS:000654836300001

SPRINGERNATURE

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Univ Queensland, Queensland Brain Inst, Clem Jones Ctr Ageing Dementia Res, Brisbane, Qld, Australia
2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
3.Southern Univ Sci & Technol, Joint Ctr Neurosci & Neural Engn, Shenzhen, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Guangdong, Peoples R China

Blackmore, Daniel G.,Turpin, Fabrice,Palliyaguru, Tishila,et al. Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling[J]. MOLECULAR PSYCHIATRY,2021.

Blackmore, Daniel G..,Turpin, Fabrice.,Palliyaguru, Tishila.,Evans, Harrison T..,Chicoteau, Antony.,...&Gotz, Jurgen.(2021).Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling.MOLECULAR PSYCHIATRY.

Blackmore, Daniel G.,et al."Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling".MOLECULAR PSYCHIATRY (2021).