Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion

Wang, Ya-Qiang1,2; Dou, Xue-Yu1,2; Wang, Hu-Fei1,2; Wang, Xing1,2; Wu, De-Cheng1,3

2021-05-01

10.1007/s10118-021-2584-1

CHINESE JOURNAL OF POLYMER SCIENCE   影响因子和分区

0256-7679

1439-6203

In recent years, the hydrogel-based tissue adhesives have been extensively investigated for their excellent biocompatibility and the ability to be administered directly within the adherent tissue. To meet the requirement for more controllable release in various physiological settings, the components of hydrogel adhesive should be more precisely tailored. In this work, the POSS-ace-PEG hydrogel adhesive was fabricated with the polyacetal dendrimer G1'-[NH3Cl](16) and poly(ethylene glycol) succinimidyl carbonate (PEG-SC) due to the regular peripheral amino structure of G1'[NH3Cl](16). Rheological and adhesion tests demonstrated that the hydrogel adhesive had good mechanical and adhesive properties, which could effectively adhere to the pigskin and severed nerves. Moreover, the tissue adhesive exhibited good stability under neutral conditions and the rapid degradation under acidic conditions, allowing for the release of doxycycline hydrochloride (DOX) drug in response to pH. Together, these results suggested that the POSS-ace-PEG adhesive had the potential to provide an alternative to tissue adhesives for applications in pathological environments (inflammation, tumors, etc.).

Hydrogel adhesive Dendrimer pH-Responsive Drug delivery Tissue adhesion

SCI ; EI

英语

通讯

Ministry of Science and Technology of China[2020YFA0908900] ; National Natural Science Foundation of China[21935011,51973226,21725403,81871782] ; Youth Innovation Promotion Association CAS[2019031]

Polymer Science

Polymer Science

WOS:000656364600001

SPRINGER

CHEMISTRY

Web of Science

1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China

Wang, Ya-Qiang,Dou, Xue-Yu,Wang, Hu-Fei,et al. Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2021.

Wang, Ya-Qiang,Dou, Xue-Yu,Wang, Hu-Fei,Wang, Xing,&Wu, De-Cheng.(2021).Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion.CHINESE JOURNAL OF POLYMER SCIENCE.

Wang, Ya-Qiang,et al."Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion".CHINESE JOURNAL OF POLYMER SCIENCE (2021).