Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance

Lai, Xuandi1; Geng, Xinran2; Li, Mengqing1; Tang, Mengxiong1; Liu, Qiong1; Yang, Mengsu3; Shen, Lin4; Zhu, Yu1; Wang, Shubin1

2021-05-01

10.2217/nnm-2021-0100

Nanomedicine   影响因子和分区

1743-5889

1748-6963

Aim: This work aims to develop an injectable nano-drug delivery system to overcome tumor multidrug resistance (MDR). Methods: A drug delivery nanoplatform based on PEGylated PLGA with glutathione (GSH) responsivity was constructed for dual delivery of doxorubicin and curcumin (termed DCNP), and its MDR reversal efficiency was studied in vitro and in vivo. Results: The DCNPs exhibited a rapid drug release profile under high GSH concentration and could enhance the cellular uptake and cytotoxicity of doxorubicin to MDR cancer cells. Moreover, the DCNPs showed better biocompatibility, longer blood circulation and enhanced antitumor efficiency compared with free drugs. Conclusion: The GSH-responsive nanocarrier is believed to be a promising candidate for overcoming tumor MDR.

cancer therapy drug delivery GSH response multidrug resistance PLGA nanoparticles

SCI

英语

其他

Shenzhen Science and Technology Innovation Commission Project["GJHZ20180420180754917","ZDSYS20190902092855097","KCXFZ20200201101050887"] ; Shenzhen Sanming Project[SZSM201612041] ; China Postdoctoral Science Foundation General Program[2018M643135]

Biotechnology & Applied Microbiology ; Science & Technology - Other Topics

Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology

WOS:000655499500001

FUTURE MEDICINE LTD

Web of Science

1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Peking Univ,Shenzhen Hosp,Dept Oncol,Med Ctr,Canc, Shenzhen Key Lab Gastrointestinal Canc Translat R, Shenzhen 518036, Peoples R China
2.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China
3.City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Lai, Xuandi,Geng, Xinran,Li, Mengqing,et al. Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance[J]. Nanomedicine,2021.

Lai, Xuandi.,Geng, Xinran.,Li, Mengqing.,Tang, Mengxiong.,Liu, Qiong.,...&Wang, Shubin.(2021).Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance.Nanomedicine.

Lai, Xuandi,et al."Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance".Nanomedicine (2021).