Bioinspired adhesive and tumor microenvironment responsive nanoMOFs assembled 3D-printed scaffold for anti-tumor therapy and bone regeneration

Jiang，Yanan1; Pan，Ximan2; Yao，Mengyu3; Han，Lu4; Zhang，Xin1; Jia，Zhanrong1; Weng，Jie1; Chen，Wenxiang2; Fang，Liming2; Wang，Xiaolan3; Zhang，Yu3; Duan，Ranxi5; Ren，Fuzeng5; Wang，Kefeng6; Chen，Xian7; Lu，Xiong1

2021-08-01

10.1016/j.nantod.2021.101182

Nano Today   影响因子和分区

1748-0132

1878-044X

Tumor-induced bone loss is the main reason causing bone tumor therapy failure. Rational design of implants with both anti-tumor and bone tissue regeneration functions is urgently needed. This study presents a 3D-printed implant that simultaneously releases anti-cancer drugs and growth factors for anti-tumor therapy and osteogenesis. Such an implant was realized by alternatively assembling polydopamine (PDA)-hybridized nanosized zeolitic imidazolate framework-8 (pZIF-8 nanoMOFs) and PDA-decorated-hydroxyapatite nanoparticles (pHA NPs) on the surfaces of the 3D-printed gelatin-based scaffolds through PDA-assisted layer-by-layer (LbL) assembly strategy. The synthesis of the pZIF-8 nanoMOFs was based on mussel-inspired catechol chemistry, which endowed the nanoMOFs with versatile adhesiveness, high drug loading efficiency, good physiological stability, and tumor environment-sensitive degradability. By using the pZIF-8 nanoMOFs as drug nanocarriers, it was possible to define the distinct spatial distribution and environmental-adaptive release patterns for BMP-2 and cisplatin from the scaffold. In vitro and in vivo studies confirmed that the scaffold possessed good osteoinductivity to induce osteogenic differentiation and to promote new bone formation. By responding to stimuli in the tumor microenvironment, the scaffolds efficiently released cisplatin and inhibited tumor growth. In short, this PDA-hybridized nanoMOF offers a new avenue to functionalize biomaterials with smart and responsive therapeutic ability for diverse biomedical applications.

3D printing scaffold Bone tumor therapy Hydroxyapatite Metal-organic framework (MOF) Polydopamine

SCI ; EI

英语

ESI高被引

其他

WOS:000687249500002

20212010358966

Adhesives ; Controlled drug delivery ; Hydroxyapatite ; Medical applications ; Rational functions ; Targeted drug delivery ; Tissue regeneration ; Tumors

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Printing Equipment:745.1.1 ; Inorganic Compounds:804.2 ; Mathematics:921

2-s2.0-85105713542

Scopus

1.Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610031,China
2.School of Materials Science and Engineering,National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou,510006,China
3.Department of Orthopedics,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,510080,China
4.School of Medicine and Pharmaceutics,Laboratory for Marine Drugs and Bioproducts,Pilot National Laboratory for Marine Science and Technology,Ocean University of China,Qingdao,266003,China
5.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
6.National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,610064,China
7.Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,610072,China

Jiang，Yanan,Pan，Ximan,Yao，Mengyu,et al. Bioinspired adhesive and tumor microenvironment responsive nanoMOFs assembled 3D-printed scaffold for anti-tumor therapy and bone regeneration[J]. Nano Today,2021,39.

Jiang，Yanan.,Pan，Ximan.,Yao，Mengyu.,Han，Lu.,Zhang，Xin.,...&Lu，Xiong.(2021).Bioinspired adhesive and tumor microenvironment responsive nanoMOFs assembled 3D-printed scaffold for anti-tumor therapy and bone regeneration.Nano Today,39.

Jiang，Yanan,et al."Bioinspired adhesive and tumor microenvironment responsive nanoMOFs assembled 3D-printed scaffold for anti-tumor therapy and bone regeneration".Nano Today 39(2021).