Delivery of manganese carbonyl to the tumor microenvironment using Tumor-Derived exosomes for cancer gas therapy and low dose radiotherapy

Zhu，Daoming1; Liu，Zeming4,5; Li，Yang2; Huang，Qinqin3; Xia，Ligang2; Li，Kaiyang1

2021-07-01

10.1016/j.biomaterials.2021.120894

BIOMATERIALS   影响因子和分区

0142-9612

1878-5905

The development of novel radiosensitizer with high selectivity and controllability is highly desirable. CO gas could cause damage to mitochondria and thus enhance RT effect. Controlled delivery of CO in tumor is important both to achieve high-efficiency of CO gas therapy and to decrease the risk of CO poisoning. In this study, manganese carbonyl (MnCO) loaded exosome nano-vesicles (MMV) to overcome this conundrum for tumor therapy is developed. After administration, MMV showed its admirable performance in active tumor-targeting, mitochondria damage and radiosensitization therapy. These MMV nanoparticles were able to facilitate robust CO evolution and consequent ROS generation in response to X-ray irradiation both in vitro and in vivo. Significantly, MMV could facilitate a 90% inhibition effect of tumor growth under very low dose (only 2Gy) RT, which is better than high dose (6Gy) radiotherapy. Overall, this study highlights a novel and practical approach to enhancing the efficacy of tumor RT, underscoring the value of future research in the field of CO medicine.

Gas therapy Low dose radiotherapy Manganese carbonyl Tumor microenvironment Tumor-derived exosomes

SCI ; EI

英语

其他

National Major Special Program of Scientific Instrument & Equipment Development of China[2012YQ160203]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000663586500002

ELSEVIER SCI LTD

MATERIALS SCIENCE

2-s2.0-85106920843

Scopus

1.Department of Electronic Science and Technology,School of Physics and Technology,Wuhan University,Wuhan,430072,China
2.Department of Gastrointestinal Surgery,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,China
3.Department of Molecular Pathology,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,450014,China
4.Department of Plastic Surgery,Zhongnan Hospital of Wuhan University,Wuhan,430071,China
5.Department of Plastic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China

Zhu，Daoming,Liu，Zeming,Li，Yang,et al. Delivery of manganese carbonyl to the tumor microenvironment using Tumor-Derived exosomes for cancer gas therapy and low dose radiotherapy[J]. BIOMATERIALS,2021,274.

Zhu，Daoming,Liu，Zeming,Li，Yang,Huang，Qinqin,Xia，Ligang,&Li，Kaiyang.(2021).Delivery of manganese carbonyl to the tumor microenvironment using Tumor-Derived exosomes for cancer gas therapy and low dose radiotherapy.BIOMATERIALS,274.

Zhu，Daoming,et al."Delivery of manganese carbonyl to the tumor microenvironment using Tumor-Derived exosomes for cancer gas therapy and low dose radiotherapy".BIOMATERIALS 274(2021).