Kinetic Resolution of 2-Substituted 1,2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation†

Cai，Baohua1; Yang，Qingjing1; Meng，Ling1,2; Wang，Jun Joelle1,2

2021-06-01

10.1002/cjoc.202000742

CHINESE JOURNAL OF CHEMISTRY   影响因子和分区

1001-604X

1614-7065

A highly efficient kinetic resolution of racemic 2-substituted 1,2-dihydroquinolines via Rh-catalyzed asymmetric hydroarylation has been described for the first time. A variety of arylboronic acids coupled with 2-substituted 1,2-dihydroquinolines under mild reaction condition. The transformations into the enantio-enriched 2,3-diaryl-tetrahydroquinolines as well as the recovered chiral 2-aryl-dihydroquinolines were obtained with high yields and excellent enantioselectivities (86%—99% ee, s factor up to 1057).

Asymmetric catalysis Hydroarylation Kinetic resolution Tetrahydroquinoline Transition metal

SCI ; IC ; CCR

英语

第一 ; 通讯

WOS:000652594600025

CHEMISTRY

2-s2.0-85106298082

Scopus

1.Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Chemistry,Hong Kong Baptist University,Kowloon,Hong Kong

Cai，Baohua,Yang，Qingjing,Meng，Ling,等. Kinetic Resolution of 2-Substituted 1,2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation†[J]. CHINESE JOURNAL OF CHEMISTRY,2021,39(6):1606-1610.

Cai，Baohua,Yang，Qingjing,Meng，Ling,&Wang，Jun Joelle.(2021).Kinetic Resolution of 2-Substituted 1,2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation†.CHINESE JOURNAL OF CHEMISTRY,39(6),1606-1610.

Cai，Baohua,et al."Kinetic Resolution of 2-Substituted 1,2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation†".CHINESE JOURNAL OF CHEMISTRY 39.6(2021):1606-1610.