Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy

Liu，Qiang1,2; Tian，Jiangwei3; Tian，Ye4; Sun，Qinchao5; Sun，Dan6; Liu，Dewen2; Wang，Feifei2; Xu，Haijun6; Ying，Guoliang7,8; Wang，Jigang1,9; Yetisen，Ali K.10; Jiang，Nan7,11

2021

10.1016/j.actbio.2021.03.064

Acta Biomaterialia   影响因子和分区

1742-7061

1878-7568

Organic fluorophores/photosensitizers have been widely used in biological imaging and photodynamic and photothermal combination therapy in the first near-infrared (NIR-I) window. However, their applications in the second near-infrared (NIR-II) window are still limited primarily due to low fluorescence quantum yields (QYs). Here, a boron dipyrromethene (BDP) is created as a molecularly engineered thiophene donor unit with high QYs to the redshift. Thiophene insertion initiates substantial redshifts of the absorbance as compared to its counterparts in which iodine is introduced. The fluorescent molecule can be triggered by an NIR laser with a single wavelength, thereby producing emission in the NIR-II windows. Single NIR laser-triggered phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and the chemotherapeutic drug docetaxel (DTX) by using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show superior solubility and high singlet oxygen QY (Φ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics. After intravenous administration of the NPs into 4T1 tumor-bearing mice, the accumulation of the NPs in the tumor showed a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the combination of photodynamic therapy (PDT) and photothermic therapy (PTT). Statement of significance: The application of organic photosensitizers is still limited primarily due to low fluorescence quantum yields (QYs) in the second near-infrared (NIR-II) window. Here, a boron dipyrromethene (BDP) as a molecularly engineered thiophene donor unit with high QYs to the redshift is created. Phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and docetaxel (DTX) using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show high singlet oxygen QY (Φ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics and a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the PDT/PTT combination therapy.

Molecular imaging NIR-II fluorophore probe Photothermal/photodynamic/chemo combination therapy Single laser triggering Thiophene donor

SCI ; EI

英语

其他

WOS:000653434900009

20215111336355

Fluorescence imaging ; Fluorescence quenching ; Infrared devices ; Laser excitation ; Mammals ; Molecular imaging ; Nanoparticles ; Photodynamic therapy ; Photosensitizers ; Polyethylene glycols ; Quantum yield ; Styrene ; Targeted drug delivery ; Thiophene ; Tumors

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Heat Treatment Processes:537.1 ; Light/Optics:741.1 ; Laser Applications:744.9 ; Imaging Techniques:746 ; Nanotechnology:761 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1 ; Solid State Physics:933

2-s2.0-85106278940

Scopus

1.Artemisinin Research Center,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,100700,China
2.Department of Chemistry,Stanford University,94305,United States
3.State Key Laboratory of Natural Medicines,Jiangsu Key Laboratory of TCM Evaluation and Translational Research,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing,21198,China
4.Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering,Biomaterials Research Center,School of Biomedical Engineering,Southern Medical University,Guangzhou,510515,China
5.Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology & Center for Biomedical Optics and Molecular Imaging,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
6.Jiangsu Co-innovation Center of Efficient Processing and Utilization of Forest Resources,College of Chemical Engineering,Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals,Nanjing Forestry University,Nanjing,210037,China
7.West China School of Basic Medical Sciences & Forensic Medicine,Sichuan University,Chengdu,610041,China
8.Brigham and Women's Hospital,Harvard Medical School,Cambridge,02139,United States
9.Department of Urology,Shenzhen People's Hospital (The First Affilated Hospital,Southern University of Science and Technology),Shenzhen,518020,China
10.Department of Chemical Engineering,Imperial College London,London,SW7 2AZ,United Kingdom
11.School of Engineering and Applied Sciences,Harvard University,Cambridge,02138,United States

Liu，Qiang,Tian，Jiangwei,Tian，Ye,et al. Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy[J]. Acta Biomaterialia,2021,127:287-297.

Liu，Qiang.,Tian，Jiangwei.,Tian，Ye.,Sun，Qinchao.,Sun，Dan.,...&Jiang，Nan.(2021).Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy.Acta Biomaterialia,127,287-297.

Liu，Qiang,et al."Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy".Acta Biomaterialia 127(2021):287-297.