Exploration of RNA helicase DHX33 as a molecular target for cancer treatment

RNA解旋酶DHX33作为肿瘤治疗分子靶点的探讨

王兴顺

11653014

博士

生物医药

仲寒冰

2020-10-22

2020-10-22

澳门大学

澳门

As a member of DEAH box RNA helicase, DHX33 has been shown to participate in a variety of cellular activities, including ribosome biogenesis, protein translation, and gene transcription. Our previous work has shown that DHX33 is a downstream transcriptional and translational target of Ras in cells. In this study we used a helicase-based high throughput screening to discover DHX33 inhibitors from Chembridge chemical library. We found that the inhibitor of DHX33 deters tumor growth in vivo. Our study for the first time demonstrates the pivotal role of the DHX33 in Ras driven lung cancer in vivo and highlights pharmacological targeting DHX33 can be a feasible option in Ras mutant lung cancers.

DHX33作为DEAH盒RNA解旋酶的一员，参与多种细胞活动，包括核糖体的生物合成、蛋白质翻译和基因转录。我们先前的研究表明DHX33是Ras在细胞中的下游转录和翻译靶点。在这项研究中，我们使用基于解旋酶的高通量筛选从Chembridge化学文库中发现DHX33抑制剂。我们发现DHX33的抑制剂抑制了体内肿瘤的生长。我们的研究首次证实了DHX33在Ras驱动的肺癌中的关键作用，并指出DHX33靶向药物治疗Ras突变型肺癌是一个可行的选择。

DHX33 RNA helicase inhibitor cancer

英语

联合培养

南方科技大学

Wang XS. Exploration of RNA helicase DHX33 as a molecular target for cancer treatment[D]. 澳门. 澳门大学,2020.