Studies toward Total Synthesis of Iriomoteolide-2a and 4-Acetoxyprobotryanes

Iriomoteolide-2a和4b-Acetoxyprobotryanes的全合成研究

张问

11651001

博士

化学

李闯创

2020-08-17

2020-08-27

香港科技大学

香港

Total synthesis of natural products is an important part of organic chemistry and has animpact on life sciences. Utilization of natural products in combating against human diseaseshas a long history and total synthesis has become an essential approach to get access tolimited supply of rare natural products and its derivatives nowadays. Besides, total synthesisenables exploration and discovery of many unprecedented and novel reactivities and efficientsynthetic strategies. This thesis research deals with total synthesis studies on two differenttypes of natural products. The first target molecule is the proposed structure ofiriomoteolide-2a, whose C6–C18 fragment has been synthesized in this thesis work. Thesecond type of target molecule is 4-acetoxyprobotryane-9,15-diol and the congeners,which contain a strained trans-[3.3.0]octane core. A novel methodology for the constructionof the strained core was explored and total synthesis 4-acetoxyprobotryane-9,15-diol hasbeen accomplished.

total synthesis Botrytis Cenera Highly strained Macrolide

英语

联合培养

南方科技大学/香港科技大学

Zhang W. Studies toward Total Synthesis of Iriomoteolide-2a and 4-Acetoxyprobotryanes[D]. 香港. 香港科技大学,2020.