Gut Microbiota Dysbiosis Correlates with Abnormal Immune Response in Moderate COVID-19 Patients with Fever

Zhou, Yaya1; Shi, Xing2,3; Fu, Wei1; Xiang, Fei1; He, Xinliang1; Yang, Bohan1; Wang, Xiaorong1; Ma, Wan-Li1

2021

10.2147/JIR.S311518

JOURNAL OF INFLAMMATION RESEARCH   影响因子和分区

1178-7031

["Background: Most COVID-19 patients are moderate, and fever is the most common clinical manifestation and associated with poorer prognosis. Gut microbiota may also play important roles in COVID-19 pathogenesis. However, the association between gut microbiota and fever in individuals with moderate COVID-19 remains unclear.","Methods: We compared the clinical features and laboratory results of 187 moderate COVID-19 patients with fever and without fever and identified several inflammatory markers in patients with fever. Then, we performed gut metagenome-wide association study for 31 individuals to identify the microbes and their epitopes which have potential role in fever and hyperinflammation.","Results: Among 187 moderate COVID-19 patients, 127 (67.9%) patients presented with fever. Lymphocytes, CD3+ T cells, CD4+ T cells and the ratio of CD4+ T cells to CD8+ T cells were significantly reduced, while AST, LDH, CRP, IL-6 and IL-10 were significantly elevated in patients with fever. Gut microbiome composition was significantly altered in patients with fever compared with those with non-fever. Opportunistic pathogens such as Enterococcus faecalis and Saccharomyces cerevisiae were enriched in patients with fever. E. faecalis was positively correlated with LDH and D-dimer and negatively correlated with CD8+T cells and IL-4, while S. cerevisiae was positively correlated with diarrhea symptom. Furthermore, several species with anti-inflammatory and protective effects, such as Bacteroides fragilis and Eubacterium ramulus, were enriched in patients with non-fever. B. fragilis was positively correlated with lymphocytes, and E. ramulus was negatively correlated with LDH, AST and IL-6. Finally, we found that several bacterial epitopes of GroEL, a homolog of human HSP60, were enriched in patients with fever and positively correlated with IL-6, IL-10, WBC, neutrophils, D-dimer, LDH, CRP, and E. faecalis.","Conclusion: Gut microbiota dysbiosis correlates with abnormal immune response in moderate COVID-19 patients with fever."]

moderate COVID-19 fever shotgun metagenomic sequencing gut microbiota epitopes

SCI

英语

其他

Fundamental Research Funds for the Central Universities["2020kfyXGYJ034","2020kfyXGYJ100"]

Immunology

Immunology

WOS:000667125400001

DOVE MEDICAL PRESS LTD

Web of Science

1.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Resp & Crit Care Med, Wuhan 430022, Peoples R China
2.Peking Univ Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Shenzhen Inst Resp Dis, Dept Pulm & Crit Care Med,Affiliated Hosp 1, Shenzhen 518020, Peoples R China

Zhou, Yaya,Shi, Xing,Fu, Wei,et al. Gut Microbiota Dysbiosis Correlates with Abnormal Immune Response in Moderate COVID-19 Patients with Fever[J]. JOURNAL OF INFLAMMATION RESEARCH,2021,14.

Zhou, Yaya.,Shi, Xing.,Fu, Wei.,Xiang, Fei.,He, Xinliang.,...&Ma, Wan-Li.(2021).Gut Microbiota Dysbiosis Correlates with Abnormal Immune Response in Moderate COVID-19 Patients with Fever.JOURNAL OF INFLAMMATION RESEARCH,14.

Zhou, Yaya,et al."Gut Microbiota Dysbiosis Correlates with Abnormal Immune Response in Moderate COVID-19 Patients with Fever".JOURNAL OF INFLAMMATION RESEARCH 14(2021).