南方科技大学知识苑(SUSTech KC): Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology

题名	Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology
作者	Lu, Kuo 1,2,3; Lai, Keng Po 4; Stoeger, Tobias 5,6; Ji, Shuqin 7; Lin, Ziyi 7; Lin, Xiao 8; Chan, Ting Fung 8; Fang, James Kar-Hei 9; Lo, Michael 10; Gao, Liang 7; Qiu, Chen 1,2,3; Chen, Shanze 1,2,3; Chen, Guobing 1,2,3,11; Li, Lei 7; Wang, Lingwei 1,2,3
通讯作者	Li, Lei; Wang, Lingwei
发表日期	2021-08-15
DOI	10.1016/j.jhazmat.2021.126069
发表期刊	JOURNAL OF HAZARDOUS MATERIALS 影响因子和分区
ISSN	0304-3894
EISSN	1873-3336
卷号	416
摘要	Concerns that airborne microplastics (MP) may be detrimental to human health are rising. However, research on the effects of MP on the respiratory system are limited. We tested the effect of MP exposure on both normal and asthmatic pulmonary physiology in mice. We show that MP exposure caused pulmonary inflammatory cell infiltration, bronchoalveolar macrophage aggregation, increased TNF-alpha level in bronchoalveolar lavage fluid (BALF), and increased plasma IgG1 production in normal mice. MP exposure also affected asthma symptoms by increasing mucus production and inflammatory cell infiltration with notable macrophage aggregation. Further, we found co-labeling of macrophage markers with MP incorporating fluorescence, which indicates phagocytosis of the MP by macrophages. A comparative transcriptomic analysis showed that MP exposure altered clusters of genes related to immune response, cellular stress response, and programmed cell death. A bioinformatics analysis further uncovered the molecular mechanism whereby MP stimulated production of tumor necrosis factor and immunoglobulins to activate a group of transmembrane B-cell antigens, leading to the modulation of cellular stress and programmed cell death in the asthma model. In summary, we show that MP exposure had detrimental effects on the respiratory system in both healthy and asthmatic mice, which calls for urgent discourse and action to mitigate environmental microplastic pollutants.
关键词	Microplastic Asthma Respiratory system Health risk Transcriptome
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
学校署名	通讯
资助项目	Key-Area Research and Development Program of Guangdong Province[2018B030331001] ; Shenzhen Science Technology and Innovative Commission (SZSTI)["JCYJ 20170307095633450","JCYJ20180508152336419"] ; Guangdong International Cooperation Grant[2019A050510032] ; Clinical research of Health and Family Planning Commission of Shenzhen Municipality[SZLY 2017024] ; National Natural Science Foundation of China (NSFC)[81770028,31971072]
WOS研究方向	Engineering ; Environmental Sciences & Ecology
WOS类目	Engineering, Environmental ; Environmental Sciences
WOS记录号	WOS:000664878600001
出版者	ELSEVIER
ESI学科分类	ENGINEERING
来源库	Web of Science
引用统计	被引频次[WOS]：80
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/230073
专题	南方科技大学第一附属医院
作者单位	1.Jinan Univ, Dept Resp Dis & Crit Care Unit, Shenzhen Inst Resp Dis, Shenzhen Key Lab Resp Dis,Shenzhen Peoples Hosp,C, Shenzhen 518020, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China 3.Jinan Univ, Postdoctoral Sci Res Stn Basic Med, Guangzhou 510632, Peoples R China 4.Guilin Med Univ, Lab Environm Pollut & Integrat Omics, Guangxi Key Lab Tumor Immunol & Microenvironm Reg, Guilin, Peoples R China 5.German Res Ctr Environm Hlth, Comprehens Pneumol Ctr, Inst Lung Biol & Dis, Helmholtz Ctr Munich, Neuherberg, Germany 6.German Ctr Lung Res, Marburg, Germany 7.Chinese Acad Sci, Guangdong Prov Key Lab Brain Connectome & Behav, CAS Key Lab Brain Connectome & Manipulat, BCBDI,Shenzhen Inst Adv Technol,Shenzhen Hong Kon, Shenzhen 518055, Peoples R China 8.Chinese Univ Hong Kong, Sch Life Sci, Hong Kong Bioinformat Ctr, Hong Kong, Peoples R China 9.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China 10.City Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China 11.Jinan Univ, Sch Med, Inst Geriatr Immunol, Dept Microbiol & Immunol, Guangzhou 510632, Guangdong, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Lu, Kuo,Lai, Keng Po,Stoeger, Tobias,et al. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,416.
APA	Lu, Kuo.,Lai, Keng Po.,Stoeger, Tobias.,Ji, Shuqin.,Lin, Ziyi.,...&Wang, Lingwei.(2021).Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology.JOURNAL OF HAZARDOUS MATERIALS,416.
MLA	Lu, Kuo,et al."Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology".JOURNAL OF HAZARDOUS MATERIALS 416(2021).