南方科技大学知识苑(SUSTech KC): Histone succinylation and its function on the nucleosome

题名	Histone succinylation and its function on the nucleosome
作者	Liu, Jiayi1,2 ; Shangguan, Yu 1,3; Tang, Donge 1,2,3; Dai, Yong 1,2,3
通讯作者	Tang, Donge; Dai, Yong
发表日期	2021-06-01
DOI	10.1111/jcmm.16676
发表期刊	JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 影响因子和分区
ISSN	1582-1838
EISSN	1582-4934
摘要	Protein post-translational modifications (PTMs) of histones are ubiquitous regulatory mechanisms involved in many biological processes, including replication, transcription, DNA damage repair and ontogenesis. Recently, many short-chain acylation histone modifications have been identified by mass spectrometry (MS). Lysine succinylation (Ksuc or Ksucc) is a newly identified histone PTM that changes the chemical environment of histones and is similar to other acylation modifications; lysine succinylation appears to accumulate at transcriptional start sites and to correlate with gene expression. Although numerous studies are ongoing, there is a lack of reviews on the Ksuc of histones. Here, we review lysine succinylation sites on histones, including the chemical characteristics and the mechanism by which lysine succinylation influences nucleosomal structure, chromatin dynamics and several diseases and then discuss lysine succinylation regulation to identify theoretical and experimental proof of Ksuc on histones and in diseases to inspire further research into histone lysine succinylation as a target of disease treatment in the future.
关键词	histone succinylation desuccinylation nucleosome
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Science and Technology Planning Project of Guangdong Province, China[2017B020209001] ; Shenzhen Key Medical Discipline Construction Fund["SZXK011","SZXK059"] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP001] ; Guangxi Key Laboratory of Metabolic Diseases Research[20-065-76]
WOS研究方向	Cell Biology ; Research & Experimental Medicine
WOS类目	Cell Biology ; Medicine, Research & Experimental
WOS记录号	WOS:000664617200001
出版者	WILEY
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
来源库	Web of Science
引用统计	被引频次[WOS]：31
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/230085
专题	南方科技大学第一附属医院南方科技大学医学院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Engn Res Ctr Autoimmune Dis, Guangdong Prov Engn Res Ctr Autoimmune Dis Precis, Shenzhen Peoples Hosp,Affiliated Hosp 1,Clin Med, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China 3.924st Hosp, Cent Lab Guilin, Guangxi Key Lab Metab Dis Res, Guilin, Peoples R China
第一作者单位	南方科技大学第一附属医院; 南方科技大学医学院
通讯作者单位	南方科技大学第一附属医院; 南方科技大学医学院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Liu, Jiayi,Shangguan, Yu,Tang, Donge,et al. Histone succinylation and its function on the nucleosome[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2021.
APA	Liu, Jiayi,Shangguan, Yu,Tang, Donge,&Dai, Yong.(2021).Histone succinylation and its function on the nucleosome.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.
MLA	Liu, Jiayi,et al."Histone succinylation and its function on the nucleosome".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021).