Saturated free fatty acids and association with memory formation

Wallis，Tristan P.1; Venkatesh，Bharat G.1; Narayana，Vinod K.1,4; Kvaskoff，David1,5; Ho，Alan2; Sullivan，Robert K.2; Windels，François2; Sah，Pankaj2,3; Meunier，Frédéric A.1

2021-12-01

10.1038/s41467-021-23840-3

Nature Communications   影响因子和分区

2041-1723

2041-1723

Polyunsaturated free fatty acids (FFAs) such as arachidonic acid, released by phospholipase activity on membrane phospholipids, have long been considered beneficial for learning and memory and are known modulators of neurotransmission and synaptic plasticity. However, the precise nature of other FFA and phospholipid changes in specific areas of the brain during learning is unknown. Here, using a targeted lipidomics approach to characterise FFAs and phospholipids across the rat brain, we demonstrated that the highest concentrations of these analytes were found in areas of the brain classically involved in fear learning and memory, such as the amygdala. Auditory fear conditioning led to an increase in saturated (particularly myristic and palmitic acids) and to a lesser extent unsaturated FFAs (predominantly arachidonic acid) in the amygdala and prefrontal cortex. Both fear conditioning and changes in FFA required activation of NMDA receptors. These results suggest a role for saturated FFAs in memory acquisition.

SCI

英语

NI期刊

其他

National Health and Medical Research Council (NHMRC)["GNT1128427","GNT1120374"] ; Australian Research Council[CE140100007] ; NHMRC[GNT1060075]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000664856900001

NATURE RESEARCH

2-s2.0-85107679346

Scopus

1.Clem Jones Centre for Ageing Dementia Research,Queensland Brain Institute,The University of Queensland,St Lucia,Australia
2.Queensland Brain Institute,The University of Queensland,St Lucia,Australia
3.Joint Center for Neuroscience and Neural Engineering,and Department of Biology,Southern University of Science and Technology,Shenzhen,China
4.Metabolomics Australia,Bio21 Institute,The University of Melbourne,Melbourne,Australia
5.Boehringer Ingelheim Pharma GmbH & Co. KG,Drug Discovery Sciences,Biberach an der Riß,Germany

Wallis，Tristan P.,Venkatesh，Bharat G.,Narayana，Vinod K.,et al. Saturated free fatty acids and association with memory formation[J]. Nature Communications,2021,12(1).

Wallis，Tristan P..,Venkatesh，Bharat G..,Narayana，Vinod K..,Kvaskoff，David.,Ho，Alan.,...&Meunier，Frédéric A..(2021).Saturated free fatty acids and association with memory formation.Nature Communications,12(1).

Wallis，Tristan P.,et al."Saturated free fatty acids and association with memory formation".Nature Communications 12.1(2021).