A biodegradable nano-photosensitizer with photoactivatable singlet oxygen generation for synergistic phototherapy

Shen，Jiaxin1,2; Chen，Dandan1; Liu，Ye1; Gao，Guoyang2; Liu，Zhihe1; Wang，Guofeng2; Wu，Changfeng1; Fang，Xiaofeng1

2021-06-28

10.1039/d1tb00937k

Journal of Materials Chemistry B   影响因子和分区

2050-750X

2050-7518

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we develop a near-infrared (NIR) light-activatable nanophotosensitizer, which shows negligible phototoxicity before photoactivation to improve the specificity of PDT. The nanophotosensitizer is prepared by indocyanine green carboxylic (ICG), Chlorin e6 (Ce6), and biodegradable poly (lactic acid) (PLA) and poly (lactic-co-glycolic acid) (PLGA), and all these materials have been approved by the Food and Drug Administration. Initially the phototoxicity of Ce6 is effectively inhibited by ICG through fluorescence resonance energy transfer (FRET). Upon 808 nm laser activation, ICG generate hyperthermia for photothermal therapy (PTT) and simultaneously is degraded due to the inherently poor photostability. The FRET is disrupted and followed by the recovery of phototoxicity of Ce6 for PDT. We investigated the photoactivation and the resulting phototherapy by cellular assays and mouse models, which indicate a superior synergistic treatment effect and selective PDT activated by near-infrared 808 nm light. This study presents a promising strategy for activatable and synergistic phototherapy with minimal damage to normal tissues.

SCI ; EI

英语

第一 ; 通讯

WOS:000661116500001

20212610570517

Energy transfer ; Forster resonance energy transfer ; Histology ; Hyperthermia therapy ; Infrared devices ; Oxygen ; Photodynamic therapy ; Photosensitizers ; Tissue ; Tissue engineering

Bioengineering and Biology:461 ; Gas Fuels:522 ; Light/Optics:741.1 ; Chemical Products Generally:804

2-s2.0-85108726860

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
2.Key Laboratory of Functional Inorganic Material Chemistry,Ministry of Education,School of Chemistry and Materials Science,Heilongjiang University,Harbin,150080,China

Shen，Jiaxin,Chen，Dandan,Liu，Ye,et al. A biodegradable nano-photosensitizer with photoactivatable singlet oxygen generation for synergistic phototherapy[J]. Journal of Materials Chemistry B,2021,9(24):4826-4831.

Shen，Jiaxin.,Chen，Dandan.,Liu，Ye.,Gao，Guoyang.,Liu，Zhihe.,...&Fang，Xiaofeng.(2021).A biodegradable nano-photosensitizer with photoactivatable singlet oxygen generation for synergistic phototherapy.Journal of Materials Chemistry B,9(24),4826-4831.

Shen，Jiaxin,et al."A biodegradable nano-photosensitizer with photoactivatable singlet oxygen generation for synergistic phototherapy".Journal of Materials Chemistry B 9.24(2021):4826-4831.