Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19

Chen, Ye1; Wang, Shouhong2; Huang, Jianrong1; Fu, Yingyun3; Wen, Juanmin4; Zhou, Chengbin5; Fu, Yang6; Liu, Lei7

2021

10.3233/CH-201080

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION   影响因子和分区

1386-0291

1875-8622

["INTRODUCTION: Coronavirus disease-19 (COVID-19) is a new type of epidemic pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The population is generally susceptible to COVID-19, which mainly causes lung injury. Some cases may develop severe acute respiratory distress syndrome (ARDS). Currently, ARDS treatment is mainly mechanical ventilation, but mechanical ventilation often causes ventilator-induced lung injury (VILI) accompanied by hypercapnia in 14% of patients. Extracorporeal carbon dioxide removal (ECCO2R) can remove carbon dioxide from the blood of patients with ARDS, correct the respiratory acidosis, reduce the tidal volume and airway pressure, and reduce the incidence of VILI.","CASE REPORT: Two patients with critical COVID-19 combined with multiple organ failure undertook mechanical ventilation and suffered from hypercapnia. ECCO2R, combined with continuous renal replacement therapy (CRRT), was conducted concomitantly. In both cases (No. 1 and 2), the tidal volume and positive end-expiratory pressure (PEEP) were down-regulated before the treatment and at 1.5 hours, one day, three days, five days, eight days, and ten days after the treatment, together with a noticeable decrease in PCO2 and clear increase in PO2, while FiO2 decreased to approximately 40%. In case No 2, compared with the condition before treatment, the PCO2 decreased significantly with down-regulation in the tidal volume and PEEP and improvement in the pulmonary edema and ARDS after the treatment.","CONCLUSION: ECCO2R combined with continuous blood purification therapy in patients with COVID-19 who are critically ill and have ARDS and hypercapnia might gain both time and opportunity in the treatment, down-regulate the ventilator parameters, reduce the incidence of VILI and achieve favorable therapeutic outcomes."]

Coronavirus disease-19 multiple organ failure hypercapnia continuous blood purification extracorporeal carbon dioxide removal

SCI

英语

第一 ; 通讯

Novel Coronavirus Infection prevention and control project of Guangdong Province[2020B1111300004]

Hematology ; Cardiovascular System & Cardiology

Hematology ; Peripheral Vascular Disease

WOS:000670662700008

IOS PRESS

CLINICAL MEDICINE

Web of Science

1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Hemopurificat Ctr,Affiliated Hosp 2, Shenzhen, Guangdong, Peoples R China
2.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Prov Geriatr Inst, Dept Crit Care Med, Guangzhou, Guangdong, Peoples R China
3.Jinan Univ, Shenzhen Peoples Hosp, Dept Pulm & Crit Care Med, Affiliated Hosp 1,Southern Univ Sci & Technol,Cli, Shenzhen, Guangdong, Peoples R China
4.Chinese Acad Med Sci, Fuwai Hosp, Shenzhen, Guangdong, Peoples R China
5.Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Prov Cardiovasc Inst, Dept Cardiovasc Surg, Guangzhou, Guangdong, Peoples R China
6.Southern Univ Sci & Technol, Sch Med, 1088 Xueyuan Ave, Shenzhen 518055, Guangdong, Peoples R China
7.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Affiliated Hosp 2, 29 Bulan Rd, Shenzhen 518100, Guangdong, Peoples R China

Chen, Ye,Wang, Shouhong,Huang, Jianrong,et al. Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2021,78(2).

Chen, Ye.,Wang, Shouhong.,Huang, Jianrong.,Fu, Yingyun.,Wen, Juanmin.,...&Liu, Lei.(2021).Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,78(2).

Chen, Ye,et al."Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 78.2(2021).