Comprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer

Yang, Mei-Feng1; Long, Xing-Xing2; Hu, Hong-Sai3; Bin, Yu-Ling3; Chen, Xuan-Ming4; Wu, Ben-Hua5,6; Peng, Quan-Zhou6,7; Wang, Li-Sheng5,6; Yao, Jun5,6; Li, De-Feng5,6

2021

10.1080/21655979.2021.1951059

Bioengineered   影响因子和分区

2165-5979

2165-5987

Synaptotagmins (SYTs), constitute a family of 17 membrane-trafficking protein, palying crucial roles in the development and progression of human cancers. However, only very few studies have investigated the expression profile and prognostic values of SYTs family members in gastric cancer (GC). Therefore, we comprehensively evaluated the expression, methylation, prognosis and immune significance of SYTs family members through bioinformatics analysis from the online databases in GC. The expressions of SYT4, SYT9, and SYT14 were up-regulated, and negatively associated with their methylation levels in GC. Both the over-expression of SYT4, SYT9 and SYT14 and their hypomethylation levels contributed to an unsatisfactory overall survival (OS) and progression-free survival (PFS) in GC. Moreover, the low expressions of several methylation cg sites (cg02795029, cg07581146, cg15149095, cg19922137, cg25371503, cg26158959, cg02269161, cg03226737, cg08185661, cg16437728, cg22723056 and cg24678137) were significantly correlated with an unfavorable OS and PFS in GC. Furthermore, the expression of SYT4, SYT9 and SYT14 played a pivotal role in immune cells infiltration in GC. Collectively, our current finding suggested that SYT4, SYT9 and SYT14 might be potent prognostic indictors and promising immunotherapeutic targets for GC patients.

Synaptotagmin-4 synaptotagmin-9 Synaptotagmin-14 prognostic values gastric cancer

SCI

英语

通讯

Natural Science Foundation of Guangdong Province[2018A0303100024] ; Three Engineering Training Funds in Shenzhen["SYLY201718","SYJY201714","SYLY201801"] ; Technical Research and Development Project of Shenzhen["JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113"] ; National Natural Science Foundation of China[81800489] ; Scientific research pro-ject of Hunan Education Department[18C0459] ; Guangdong Province Health Planning Commission[A2021117]

Biotechnology & Applied Microbiology

Biotechnology & Applied Microbiology

WOS:000670448500001

TAYLOR & FRANCIS INC

Web of Science

1.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Guangdong, Peoples R China
2.South China Univ, Affiliated Hosp 1, Dept Hematol, Hengyang, Hunan, Peoples R China
3.Xiangya Med Coll, Dept Gastroenterol, Affiliated Zhuzhou Hosp, Zhuzhou, Hunan, Peoples R China
4.South China Univ, Affiliated Hosp 1, Dept Gastroenterol, Hengyang, Hunan, Peoples R China
5.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Gastroenterol, Shenzhen, Guangdong, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
7.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Pathol, Shenzhen, Guangdong, Peoples R China

Yang, Mei-Feng,Long, Xing-Xing,Hu, Hong-Sai,et al. Comprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer[J]. Bioengineered,2021,12(1).

Yang, Mei-Feng.,Long, Xing-Xing.,Hu, Hong-Sai.,Bin, Yu-Ling.,Chen, Xuan-Ming.,...&Li, De-Feng.(2021).Comprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer.Bioengineered,12(1).

Yang, Mei-Feng,et al."Comprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer".Bioengineered 12.1(2021).