Comparison of Clinical Characteristics Among COVID-19 and Non-COVID-19 Pediatric Pneumonias: A Multicenter Cross-Sectional Study

Jia, Zhongwei1,2,3; Yan, Xiangyu1,2,3; Gao, Liwei4,5; Ding, Shenggang6; Bai, Yan7; Zheng, Yuejie8; Cui, Yuxia9; Wang, Xianfeng10; Li, Jingfeng11; Lu, Gen12; Xu, Yi12; Zhang, Xiangyu1,2,3; Li, Junhua13; Chen, Ning14; Shang, Yunxiao14; Han, Mingfeng15; Liu, Jun16; Zhou, Hourong17,18; Li, Cen9; Lu, Wanqiu19; Liu, Jun4,5; Wang, Lina4,5; Fan, Qihong20; Wu, Jiang21; Shen, Hanling22; Jiao, Rong23; Chen, Chunxi24; Gao, Xiaoling25; Tian, Maoqiang26; Lu, Wei27; Yang, Yonghong28,29; Wong, Gary Wing-Kin30; Wang, Tianyou31; Jin, Runming7; Shen, Adong32; Xu, Baoping4,5; Shen, Kunling4

2021-07-01

10.3389/fcimb.2021.663884

Frontiers in Cellular and Infection Microbiology   影响因子和分区

2235-2988

Background The pandemic of Coronavirus Disease 2019 (COVID-19) brings new challenges for pediatricians, especially in the differentiation with non-COVID-19 pneumonia in the peak season of pneumonia. We aimed to compare the clinical characteristics of pediatric patients with COVID-19 and other respiratory pathogens infected pneumonias. Methods We conducted a multi-center, cross-sectional study of pediatric inpatients in China. Based on pathogenic test results, pediatric patients were divided into three groups, including COVID-19 pneumonia group, Non-COVID-19 viral (NCV) pneumonia group and Non-viral (NV) pneumonia group. Their clinical characteristics were compared by Kruskal-Wallis H test or chi-square test. Results A total of 636 pediatric pneumonia inpatients, among which 87 in COVID-19 group, 194 in NCV group, and 355 in NV group, were included in analysis. Compared with NCV and NV patients, COVID-19 patients were older (median age 6.33, IQR 2.00-12.00 years), and relatively fewer COVID-19 patients presented fever (63.2%), cough (60.9%), shortness of breath (1.1%), and abnormal pulmonary auscultation (18.4%). The results were verified by the comparison of COVID-19, respiratory syncytial virus (RSV) and influenza A (IFA) pneumonia patients. Approximately 42.5%, 44.8%, and 12.6% of the COVID-19 patients presented simply ground-glass opacity (GGO), simply consolidation, and the both changes on computed tomography (CT) scans, respectively; the proportions were similar as those in NCV and NV group (p>0.05). Only 47.1% of COVID-19 patients had both lungs pneumonia, which was significantly lower than that proportion of nearly 80% in the other two groups. COVID-19 patients presented lower proportions of increased white blood cell count (16.5%) and abnormal procalcitonin (PCT) (10.7%), and a higher proportion of decreased lymphocyte count (44.0%) compared with the other two groups. Conclusion Majority clinical characteristics of pediatric COVID-19 pneumonia patients were milder than non-COVID-19 patients. However, lymphocytopenia remained a prominent feature of COVID-19 pediatric pneumonia.

COVID-19 pneumonia viral pneumonia non-viral pneumonia pediatric patients clinical characteristics

SCI

英语

其他

National Natural Science Foundation of China[91546203,91846302] ; CAMS Innovation Fund for Medical Sciences (CIFMS)["2019-12M-5-026","2020-I2M-CT-B-098"]

Immunology ; Microbiology

Immunology ; Microbiology

WOS:000673596700001

FRONTIERS MEDIA SA

Web of Science

1.Peking Univ, Sch Publ Hlth, Beijing, Peoples R China
2.Peking Univ, Ctr Intelligent Publ Hlth, Inst Artificial Intelligence, Beijing, Peoples R China
3.Peking Univ, Ctr Drug Abuse Control & Prevent, Natl Inst Hlth Data Sci, Beijing, Peoples R China
4.Capital Med Univ, China Natl Clin Res Ctr Resp Dis, Natl Ctr Childrens Hlth, Dept Resp Med,Beijing Childrens Hosp, Beijing, Peoples R China
5.Chinese Acad Med Sci, Res Unit Crit Infect Children, Beijing, Peoples R China
6.Anhui Med Univ, Dept Pediat, Affiliated Hosp 1, Hefei, Peoples R China
7.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Pediat Dept, Wuhan, Hubei, Peoples R China
8.Shenzhen Childrens Hosp, Dept Resp Med, Shenzhen, Peoples R China
9.Guizhou Prov Peoples Hosp, Dept Pediat, Guiyang, Guizhou, Peoples R China
10.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Dept Pediat, Affiliated Hosp 2, Shenzhen, Peoples R China
11.Taihe Hosp, Dept Pediat, Shiyan, Peoples R China
12.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Pediat, Guangzhou, Peoples R China
13.Xiangyang Cent Hosp, Dept Pediat, Xiangyang, Peoples R China
14.China Med Univ, Dept Pediat, Shengjing Hosp, Shenyang, Liaoning, Peoples R China
15.Second Peoples Hosp Fuyang, Dept Resp Med, Fuyang, Anhui, Peoples R China
16.People Hosp Bozhou, Dept Pediat, Bozhou, Anhui, Peoples R China
17.Guizhou Prov Peoples Hosp, Dept Gen Practice, Guiyang, Guizhou, Peoples R China
18.Jiangjunshan Hosp, Off Acad Res, Guiyang, Guizhou, Peoples R China
19.Guizhou Univ, Dept Pediat, Affiliated Hosp, Guiyang, Guizhou, Peoples R China
20.Jingzhou First Peoples Hosp, Dept Pediat, Jingzhou, Peoples R China
21.Huangshi Matern & Child Hlth Care Hosp, Dept Pediat, Huangshi, Hubei, Peoples R China
22.Suizhou Matern & Child Hlth Care Hosp, Dept Pediat, Suizhou, Peoples R China
23.Xiangyang First Peoples Hosp, Dept Pediat, Xiangyang, Peoples R China
24.Xishui Peoples Hosp, Dept Pediat, Huanggang, Peoples R China
25.Peoples Hosp Tuanfeng Cty, Dept Pediat, Huanggang, Peoples R China
26.Tongren Peoples Hosp Guizhou Prov, Dept Pediat, Tongren, Guizhou, Peoples R China
27.Yichang Cent Peoples Hosp, Dept Pediat, Yichang, Peoples R China
28.Beijing Pediat Res Inst, Beijing, Peoples R China
29.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Beijing, Peoples R China
30.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Pediat, Hong Kong, Peoples R China
31.Capital Med Univ, Beijing Childrens Hosp, Ctr Hematol Oncol, Natl Ctr Childrens Hlth, Beijing, Peoples R China
32.Capital Med Univ, Natl Ctr Childrens Hlth, Beijing Pediat Res Inst, Beijing Key Lab Pediat Resp Infect Dis,Beijing Ch, Beijing, Peoples R China

Jia, Zhongwei,Yan, Xiangyu,Gao, Liwei,et al. Comparison of Clinical Characteristics Among COVID-19 and Non-COVID-19 Pediatric Pneumonias: A Multicenter Cross-Sectional Study[J]. Frontiers in Cellular and Infection Microbiology,2021,11.

Jia, Zhongwei.,Yan, Xiangyu.,Gao, Liwei.,Ding, Shenggang.,Bai, Yan.,...&Shen, Kunling.(2021).Comparison of Clinical Characteristics Among COVID-19 and Non-COVID-19 Pediatric Pneumonias: A Multicenter Cross-Sectional Study.Frontiers in Cellular and Infection Microbiology,11.

Jia, Zhongwei,et al."Comparison of Clinical Characteristics Among COVID-19 and Non-COVID-19 Pediatric Pneumonias: A Multicenter Cross-Sectional Study".Frontiers in Cellular and Infection Microbiology 11(2021).