| 题名 | Uncovering the Subtype-Specific Molecular Characteristics of Breast Cancer by Multiomics Analysis of Prognosis-Associated Genes, Driver Genes, Signaling Pathways, and Immune Activity |
| 作者 | |
| 通讯作者 | Zhu, Yuanyuan; Zhang, Minghui; Tang, Jing |
| 发表日期 | 2021-07-01
|
| DOI | |
| 发表期刊 | |
| ISSN | 2296-634X
|
| 卷号 | 9 |
| 摘要 | Breast cancer is a heterogeneous malignant disease with different prognoses and has been divided into four molecular subtypes. It is believed that molecular events occurring in breast stem/progenitor cells contribute to the carcinogenesis and development of different breast cancer subtypes. However, these subtype-specific molecular characteristics are largely unknown. In this study, we employed 1217 breast cancer samples from The Cancer Genome Atlas (TCGA) database for a multiomics analysis of the molecular characteristics of different breast cancer subtypes based on PAM50 algorithms. We detected the expression changes of subtype-specific genes and revealed that the expression of particular subtype-specific genes significantly affected prognosis. We also investigated the mutations and copy number variations (CNVs) of breast cancer driver genes and the representative genes of ten signaling pathways in different subtypes and revealed several subtype-specifically altered genes. Moreover, we detected the infiltration of various immune cells in different subtypes of breast cancer and showed that the infiltration levels of major immune cell types are different among these subtypes. Additionally, we investigated the factors affecting the immune infiltration level and the immune cytolytic activity in different breast cancer subtypes, namely, the mutation burden, genome instability and cancer-associated fibroblast (CAF) infiltration. This study may shed light on the molecular events contributing to carcinogenesis and development and provide potential markers and targets for the clinical diagnosis and treatment of different breast cancer subtypes. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 其他
|
| 资助项目 | Natural Science Foundation of Inner Mongolia[2020MS08084]
; Inner Mongolia Science & Technology Plan Project[201802133,"2020GG0297"]
|
| WOS研究方向 | Cell Biology
; Developmental Biology
|
| WOS类目 | Cell Biology
; Developmental Biology
|
| WOS记录号 | WOS:000673556700001
|
| 出版者 | |
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：12
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/240240 |
| 专题 | 南方科技大学医学院 |
| 作者单位 | 1.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China 3.Peoples Hosp Liaoning Prov, Dept Pathol, Shenyang, Peoples R China 4.Harbin Med Univ, Dept Pathol, Harbin, Peoples R China 5.Chifeng City Hosp, Dept Oncol, Chifeng, Peoples R China 6.Chifeng City Hosp, Dept Pathol, Chifeng, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Li, Xinhui,Zhou, Jian,Xiao, Mingming,et al. Uncovering the Subtype-Specific Molecular Characteristics of Breast Cancer by Multiomics Analysis of Prognosis-Associated Genes, Driver Genes, Signaling Pathways, and Immune Activity[J]. Frontiers in Cell and Developmental Biology,2021,9.
|
| APA |
Li, Xinhui.,Zhou, Jian.,Xiao, Mingming.,Zhao, Lingyu.,Zhao, Yan.,...&Tang, Jing.(2021).Uncovering the Subtype-Specific Molecular Characteristics of Breast Cancer by Multiomics Analysis of Prognosis-Associated Genes, Driver Genes, Signaling Pathways, and Immune Activity.Frontiers in Cell and Developmental Biology,9.
|
| MLA |
Li, Xinhui,et al."Uncovering the Subtype-Specific Molecular Characteristics of Breast Cancer by Multiomics Analysis of Prognosis-Associated Genes, Driver Genes, Signaling Pathways, and Immune Activity".Frontiers in Cell and Developmental Biology 9(2021).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
;
修改评论