Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults

Chen, Dandan1; Zhang, Yu1; Yao, Can1; Li, Binbin2; Li, Sinian1; Liu, Wenwen2; Chen, Rongchang1; Shi, Fei2

2021-07-05

10.1186/s13223-021-00568-9

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY   影响因子和分区

1710-1492

BackgroundDifferences between adult patients with severe early-onset and late-onset asthma have not been well studied.ObjectivesTo determine the phenotypic distinction regarding age at onset in patients with severe asthma.MethodsThe present study enrolled thirty-two patients with severe early-onset (onset age<12 years) asthma and thirty-two patients with severe late-onset (onset age>12 years) asthma. Severe asthma was defined according to Global Initiative for Asthma criteria. The clinical, spirometric, and laboratory parameters were collected for group comparisons.ResultsAmong the 64 patients included (mean age, 46.2213.90 years; 53.1% male), the mean percent of predicted forced expiratory volume in 1 s (FEV1) was 68.43 +/- 20.55%. Patients with severe early-onset asthma had a younger age, longer duration of asthma, higher rate of family history, and better small-airway function (MEF25% and MMEF75/25%) compared with severe late-onset asthma. Furthermore, levels of serum IL-17 and sputum neutrophil percentage were significantly higher for patients with severe early-onset asthma (P=0.016, 0.033, respectively). Multiple logistic regression analysis revealed that increased serum IL-17 (odds ratio=1.065, P=0.016) was independently associated with severe early-onset asthma. The combination of serum IL-17 and sputum neutrophil percentage yielded a sensitivity of 80.0% and a specificity of 86.7% for identifying patients with severe early-onset asthma.Conclusions Patients with severe early-onset asthma exhibit elevated levels of serum IL-17 and sputum neutrophil percentage, suggesting a potential role in the pathogenesis of severe early-onset phenotype.

Early-onset Severe asthma IL-17 Neutrophil

SCI

英语

第一 ; 通讯

Natural Science Foundation of China[81300012] ; Natural Science Foundation of Guangdong Province, China[2020A151501040] ; Scientific Research and Cultivation Project of Shenzhen People's Hospital[SYKYPY201912]

Allergy ; Immunology

Allergy ; Immunology

WOS:000672469000002

BMC

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1,Key Lab Shenzhen Resp Dis, Shenzhen Peoples Hosp,Clin Med Coll 2,Inst Shenzh, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1,Emergency Dept,Key Lab Shenzhen, Clin Med Coll 2,Inst Shenzhen Resp Dis,Shenzhen P, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China

Chen, Dandan,Zhang, Yu,Yao, Can,et al. Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults[J]. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY,2021,17(1).

Chen, Dandan.,Zhang, Yu.,Yao, Can.,Li, Binbin.,Li, Sinian.,...&Shi, Fei.(2021).Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults.ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY,17(1).

Chen, Dandan,et al."Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults".ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY 17.1(2021).