| 题名 | Safety and effectiveness of SARS-CoV-2 vaccines: A systematic review and meta-analysis |
| 作者 | |
| 通讯作者 | Ling, Yunzhi |
| 发表日期 | 2021-07-01
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| DOI | |
| 发表期刊 | |
| ISSN | 0146-6615
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| EISSN | 1096-9071
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| 摘要 | Objective: To systematically evaluate the effectiveness and safety of the SARS-CoV-2 vaccines currently undergoing clinical trials. Methods: PubMed, EMBASE, and Cochrane Library databases were searched to collect open human COVID-19 vaccines randomized controlled trials, without limiting the search time and language. The research papers collected in the above-mentioned databases were initially screened according to the title and abstract content and merged, and the repeated ones were removed. After reading the full text of the remaining research, the studies that did not meet the inclusion criteria were excluded, and finally, nine studies were obtained. After extracting the statistical data of adverse events in the study, load them into Review Manager for heterogeneity analysis. Results: The incidence of adverse reactions of inactivated virus vaccines, RNA vaccines, and adenovirus vector vaccines was higher than that of placebo. Common adverse reactions included pain, swelling, and fever at the injection site. Conclusion: From the perspective of effectiveness, RNA vaccine > adenovirus vector vaccine > inactivated virus vaccine. From the perspective of safety, the incidence of adverse reactions of the three vaccines is higher than that of a placebo, and the incidence of adverse reactions of the adenovirus vector vaccine is higher. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 第一
; 通讯
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| WOS研究方向 | Virology
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| WOS类目 | Virology
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| WOS记录号 | WOS:000679335100001
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| 出版者 | |
| ESI学科分类 | MICROBIOLOGY
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：53
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/240286 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Ctr Lab Longhua Branch, Affiliated Hosp 1,Clin Med Coll 2,Dept Infect Dis, Shenzhen 518020, Guangdong, Peoples R China 2.Algae Co, Dept Res Ctr, Guangzhou, Peoples R China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Ling, Yunzhi,Zhong, Jiaying,Luo, Jiaru. Safety and effectiveness of SARS-CoV-2 vaccines: A systematic review and meta-analysis[J]. JOURNAL OF MEDICAL VIROLOGY,2021.
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| APA |
Ling, Yunzhi,Zhong, Jiaying,&Luo, Jiaru.(2021).Safety and effectiveness of SARS-CoV-2 vaccines: A systematic review and meta-analysis.JOURNAL OF MEDICAL VIROLOGY.
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| MLA |
Ling, Yunzhi,et al."Safety and effectiveness of SARS-CoV-2 vaccines: A systematic review and meta-analysis".JOURNAL OF MEDICAL VIROLOGY (2021).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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