Wearable Intracranial Pressure Monitoring Sensor for Infants

Zhang, Baoyue1; Huang, Ziyi1; Song, Huixue1; Kim, Hyun Soo2; Park, Jaewon1

2021-07-01

10.3390/bios11070213

BIOSENSORS-BASEL   影响因子和分区

2079-6374

Monitoring of intracranial pressure (ICP) is important for patients at risk of raised ICP, which may indicate developing diseases in brains that can lead to brain damage or even death. Monitoring ICP can be invaluable in the management of patients suffering from brain injury or hydrocephalus. To date, invasive measurements are still the standard method for monitoring ICP; however, these methods can not only cause bleeding or infection but are also very inconvenient to use, particularly for infants. Currently, none of the non-invasive methods can provide sufficient accuracy and ease of use while allowing continuous monitoring in routine clinical use at low cost. Here, we have developed a wearable, non-invasive ICP sensor that can be used like a band-aid. For the fabrication of the ICP sensor, a novel freeze casting method was developed to encapsulate the liquid metal microstructures within thin and flexible polymers. The final thickness of the ICP sensor demonstrated is 500 p.m and can be further reduced. Three different designs of ICP sensors were tested under various pressure actuation conditions as well as different temperature environments, where the measured pressure changes were stable with the largest stability coefficient of variation being only CV = 0.0206. In addition, the sensor output values showed an extremely high linear correlation (R-2 > 0.9990) with the applied pressures.

wearable sensor intracranial pressure sensor liquid metal freeze casting

SCI ; EI

英语

第一 ; 通讯

Shenzhen Basic Research Grant[JCYJ-20180504165801830] ; National Research Foundation of Korea - Ministry of Education[NRF2018R1A6A1A03025242] ; Korean government[NRF-2021R1F1A1063455]

Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation

Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation

WOS:000677375900001

MDPI

Web of Science

1.Southern Univ Sci & Technol, Sch Microelect, Shenzhen 518055, Peoples R China
2.Kwangwoon Univ, Dept Elect Engn, Seoul 01897, South Korea

Zhang, Baoyue,Huang, Ziyi,Song, Huixue,et al. Wearable Intracranial Pressure Monitoring Sensor for Infants[J]. BIOSENSORS-BASEL,2021,11(7).

Zhang, Baoyue,Huang, Ziyi,Song, Huixue,Kim, Hyun Soo,&Park, Jaewon.(2021).Wearable Intracranial Pressure Monitoring Sensor for Infants.BIOSENSORS-BASEL,11(7).

Zhang, Baoyue,et al."Wearable Intracranial Pressure Monitoring Sensor for Infants".BIOSENSORS-BASEL 11.7(2021).