南方科技大学知识苑(SUSTech KC): IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis

题名	IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis
作者	Huang, Rongxiang 1,2; Zhang Hui 1,2; Sun Wei 1; Duan Li 1; Li, Wencui 1; Wang Daping 1,2; Alandal, Murad 1,3,4
通讯作者	Li, Wencui; Wang Daping; Alandal, Murad
发表日期	2021-07-01
DOI	10.1002/jcp.30537
发表期刊	JOURNAL OF CELLULAR PHYSIOLOGY 影响因子和分区
ISSN	0021-9541
EISSN	1097-4652
摘要	IRE1 is an important central regulator of unfolded protein response (UPR) in the endoplasmic reticulum (ER) because of its ability to regulate cell fate as a function of stress sensing. When misfolded proteins accumulated in chondrocytes ER, IRE1 disintegrates with BIP/GRP78 and undergoes dimer/oligomerization and transautophosphorylation. These two processes are mediated through an enzyme activity of IRE1 to activate endoribonuclease and generates XBP1 by unconventional splicing of XBP1 messenger RNA. Thereby promoting the transcription of UPR target genes and apoptosis. The deficiency of inositol-requiring enzyme 1 alpha (IRE1 alpha) in chondrocytes downregulates prosurvival factors XBP1S and Bcl-2, which enhances the apoptosis of chondrocytes through increasing proapoptotic factors caspase-3, p-JNK, and CHOP. Meanwhile, the activation of IRE1 alpha increases chondrocyte viability and reduces cell apoptosis. However, the understanding of IRE1 responses and cell death fate remains controversial. This review provides updated data about the role IRE1 plays in chondrocytes and new insights about the potential efficacy of IRE1 regulation in cartilage repair and osteoarthritis treatment.
关键词	apoptosis chondrocyte ERS IRE1 osteoarthritis
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	International Science and Technology Cooperation Project of Guangdong Province 2019, China[1035043] ; National Natural Science Foundation of China[81772394,81972116,81972085] ; key clinical discipline of Guangdong Province, Orthopaedics[2000005]
WOS研究方向	Cell Biology ; Physiology
WOS类目	Cell Biology ; Physiology
WOS记录号	WOS:000676110600001
出版者	WILEY
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
来源库	Web of Science
引用统计	被引频次[WOS]：38
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/240335
专题	工学院_生物医学工程系
作者单位	1.Shenzhen Univ, Guangdong Prov Res Ctr Artificial Intelligence &, Shenzhen Lab Digital Orthoped Engn,Hosp 1,Hlth Sc, Shenzhen Key Lab Tissue Engn,Shenzhen Peoples Hos, Shenzhen, Peoples R China 2.Univ South China, Clin Med Dept, Sch Med, Hengyang, Peoples R China 3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China 4.Hodeidah Univ, Dept Med Labs, Al Hudaydah, Yemen
通讯作者单位	生物医学工程系
推荐引用方式 GB/T 7714	Huang, Rongxiang,Zhang Hui,Sun Wei,et al. IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2021.
APA	Huang, Rongxiang.,Zhang Hui.,Sun Wei.,Duan Li.,Li, Wencui.,...&Alandal, Murad.(2021).IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis.JOURNAL OF CELLULAR PHYSIOLOGY.
MLA	Huang, Rongxiang,et al."IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis".JOURNAL OF CELLULAR PHYSIOLOGY (2021).